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    RKP uncharacterized protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816737, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RKP
    Official Full Name
    uncharacterized protein
    Primary source
    TAIR:AT2G22010
    Locus tag
    AT2G22010
    See related
    Araport:AT2G22010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT2G22020; F7D8.33; F7D8_33; related to KPC1
    Summary
    Encodes a protein predicted to act as a RING E3 ubiquitin ligase. It appears to regulate the stability of the KRP1/ICK1 cyclin dependent kinase inhibitor. Induced by beet severe curly virus (BSCTV) C4 protein.
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    Genomic context

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    See RKP in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (9363109..9369461, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene MIZU-KUSSEI-like protein (Protein of unknown function, DUF617) Neighboring gene elicitor peptide 6 precursor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Degradation of the cyclin-dependent kinase inhibitor KRP1 is regulated by two different ubiquitin E3 ligases. Ren H, et al. Plant J, 2008 Mar. PMID 18005227
    2. RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle. Lai J, et al. Plant J, 2009 Mar. PMID 19000158
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RKP is a RING finger E3 ligase induced by Beet severe curly top virus C4 protein, and may affect BSCTV infection by regulating the host cell cycle.
      Title: RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202644.1
    NM_179689.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-ubiquitin ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001189573.1
    • related to KPC1 (RKP); FUNCTIONS IN: zinc ion binding; INVOLVED IN: regulation of cell cycle, response to virus, proteolysis involved in cellular protein catabolic process; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), SPla/RYanodine receptor subgroup (InterPro:IPR018355), B302 (SPRY)-like (InterPro:IPR001870), SPla/RYanodine receptor SPRY (InterPro:IPR003877).
    NP_850020.1
    • related to KPC1 (RKP); FUNCTIONS IN: zinc ion binding; INVOLVED IN: regulation of cell cycle, response to virus, proteolysis involved in cellular protein catabolic process; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), SPla/RYanodine receptor subgroup (InterPro:IPR018355), B302 (SPRY)-like (InterPro:IPR001870), SPla/RYanodine receptor SPRY (InterPro:IPR003877); Has 1690 Blast hits to 1529 proteins in 192 species: Archae - 0; Bacteria - 13; Metazoa - 1117; Fungi - 103; Plants - 141; Viruses - 2; Other Eukaryotes - 314 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9363109..9369461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202644.1 → NP_001189573.1  uncharacterized protein AT2G22010 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VZB5, F4IIK4
      Conserved Domains (3) summary
      pfam10408
      Location:852 → 949
      Ufd2P_core; Ubiquitin elongating factor core
      pfam13920
      Location:1216 → 1264
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd12882
      Location:137 → 265
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

    2. NM_179689.3 → NP_850020.1  uncharacterized protein AT2G22010 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850020.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIZ8
      UniProtKB/TrEMBL
      A0A178VZB5, A0A5S9X0G3, A0A654EWH8
      Conserved Domains (3) summary
      cd12882
      Location:137 → 265
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
      cd16541
      Location:1215 → 1255
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins
      pfam10408
      Location:852 → 949
      Ufd2P_core; Ubiquitin elongating factor core
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIZ8.2

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