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    AAO3 abscisic aldehyde oxidase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817257, updated on 2-Oct-2024

    Summary

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    Official Symbol
    AAO3
    Official Full Name
    abscisic aldehyde oxidase 3
    Primary source
    TAIR:AT2G27150
    Locus tag
    AT2G27150
    See related
    Araport:AT2G27150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    abscisic aldehyde oxidase 3; ABSCISIC ALDEHYDE OXIDASE 3; Aldehyde oxidase delta; AOdelta; Arabidopsis thaliana aldehyde oxidase 3; At-AO3; AtAAO3; F20F1.2; F20F1_2
    Summary
    Encodes the aldehyde oxidase delta isoform catalyzing the final step in abscisic acid biosynthesis.
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    Genomic context

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    See AAO3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (11601727..11608450)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene low-molecular-weight cysteine-rich 9 Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes (SMC) family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis aldehyde oxidase 3, known to oxidize abscisic aldehyde to abscisic acid, protects leaves from aldehyde toxicity. Nurbekova Z, et al. Plant J, 2021 Dec. PMID 34587326
    2. Nitric oxide- induced AtAO3 differentially regulates plant defense and drought tolerance in Arabidopsis thaliana. Khan M, et al. BMC Plant Biol, 2019 Dec 30. PMID 31888479, Free PMC Article
    3. The Arabidopsis aldehyde oxidase 3 (AAO3) gene product catalyzes the final step in abscisic acid biosynthesis in leaves. Seo M, et al. Proc Natl Acad Sci U S A, 2000 Nov 7. PMID 11050171, Free PMC Article
    4. Abscisic aldehyde oxidase in leaves of Arabidopsis thaliana. Seo M, et al. Plant J, 2000 Aug. PMID 10972874
    5. AAO2 impairment enhances aldehyde detoxification by AAO3 in Arabidopsis leaves exposed to UV-C or Rose-Bengal. Nurbekova Z, et al. Plant J, 2024 Oct. PMID 39190782

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AAO2 impairment enhances aldehyde detoxification by AAO3 in Arabidopsis leaves exposed to UV-C or Rose-Bengal.
      Title: AAO2 impairment enhances aldehyde detoxification by AAO3 in Arabidopsis leaves exposed to UV-C or Rose-Bengal.
    2. Arabidopsis aldehyde oxidase 3, known to oxidize abscisic aldehyde to abscisic acid, protects leaves from aldehyde toxicity.
      Title: Arabidopsis aldehyde oxidase 3, known to oxidize abscisic aldehyde to abscisic acid, protects leaves from aldehyde toxicity.
    3. AtAO3 negatively regulates pathogen-induced salicylic acid pathway, although it is required for drought tolerance, despite the fact that ABA production is not totally dependent on AtAO3.
      Title: Nitric oxide- induced AtAO3 differentially regulates plant defense and drought tolerance in Arabidopsis thaliana.
    4. NAP promotes chlorophyll degradation by enhancing transcription of AAO3, which leads to increased levels of the senescence-inducing hormone ABA.
      Title: A NAP-AAO3 regulatory module promotes chlorophyll degradation via ABA biosynthesis in Arabidopsis leaves.
    5. In addition to their aldehyde oxidation activity, AAO1 and AAO3 were found to exhibit NADH oxidase activity, which likewise is associated with the production of superoxide anions.
      Title: Identification of superoxide production by Arabidopsis thaliana aldehyde oxidases AAO1 and AAO3.
    6. AAO3 is overexpressed in ataf1 plants compared to wild-type plants following inoculation with Bgh.
      Title: Transcriptional regulation by an NAC (NAM-ATAF1,2-CUC2) transcription factor attenuates ABA signalling for efficient basal defence towards Blumeria graminis f. sp. hordei in Arabidopsis.
    7. The competence of stomatal guard cells in V. faba to synthesize abscisic acid, using NCED3 and AAO3 from A. thaliana, is reported.
      Title: Transient expression of AtNCED3 and AAO3 genes in guard cells causes stomatal closure in Vicia faba.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001084497.1
    NM_001336104.1
    NM_001336105.1
    NM_001336106.1
    NM_001336107.1
    NM_128273.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables abscisic aldehyde oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables indole-3-acetaldehyde oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    abscisic aldehyde oxidase 3
    NP_001077966.1
    • abscisic aldehyde oxidase 3 (AAO3); CONTAINS InterPro DOMAIN/s: Aldehyde oxidase/xanthine dehydrogenase (InterPro:IPR016208), Ferredoxin (InterPro:IPR001041), Molybdopterin dehydrogenase, FAD-binding (InterPro:IPR002346), [2Fe-2S]-binding (InterPro:IPR002888), FAD-binding, type 2 (InterPro:IPR016166), CO dehydrogenase flavoprotein, C-terminal (InterPro:IPR005107), 2Fe-2S ferredoxin, iron-sulphur binding site (InterPro:IPR006058), CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 (InterPro:IPR016169), Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (InterPro:IPR000674), Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding (InterPro:IPR008274); BEST Arabidopsis thaliana protein match is: aldehyde oxidase 4 (TAIR:AT1G04580.1); Has 18285 Blast hits to 17524 proteins in 1277 species: Archae - 409; Bacteria - 10745; Metazoa - 1018; Fungi - 113; Plants - 280; Viruses - 0; Other Eukaryotes - 5720 (source: NCBI BLink).
    NP_180283.1
    • abscisic aldehyde oxidase 3 (AAO3); CONTAINS InterPro DOMAIN/s: Aldehyde oxidase/xanthine dehydrogenase (InterPro:IPR016208), Ferredoxin (InterPro:IPR001041), Molybdopterin dehydrogenase, FAD-binding (InterPro:IPR002346), [2Fe-2S]-binding (InterPro:IPR002888), FAD-binding, type 2 (InterPro:IPR016166), CO dehydrogenase flavoprotein, C-terminal (InterPro:IPR005107), 2Fe-2S ferredoxin, iron-sulphur binding site (InterPro:IPR006058), CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 (InterPro:IPR016169), Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (InterPro:IPR000674), Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding (InterPro:IPR008274); BEST Arabidopsis thaliana protein match is: aldehyde oxidase 4 (TAIR:AT1G04580.1); Has 18285 Blast hits to 17524 proteins in 1277 species: Archae - 409; Bacteria - 10745; Metazoa - 1018; Fungi - 113; Plants - 280; Viruses - 0; Other Eukaryotes - 5720 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11601727..11608450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128273.3 → NP_180283.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180283.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64429, Q7G9P4, Q7GD73, Q9SIG7, Q9SLZ2
      UniProtKB/TrEMBL
      A0A178VZD9
      Conserved Domains (6) summary
      PLN00192
      Location:1 → 1331
      PLN00192; aldehyde oxidase
      pfam00941
      Location:223 → 398
      FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
      pfam01315
      Location:579 → 689
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      pfam01799
      Location:84 → 162
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:718 → 1239
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:412 → 520
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

    2. NM_001336104.1 → NP_001324268.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZK7, A0A5S9X1K9

    3. NM_001336105.1 → NP_001324270.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VZD9, A0A1P8AZL6

    4. NM_001336106.1 → NP_001324271.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZL3, A0A5S9X1K9

    5. NM_001084497.1 → NP_001077966.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077966.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64429, Q7G9P4, Q7GD73, Q9SIG7, Q9SLZ2
      UniProtKB/TrEMBL
      A0A178VZD9
      Conserved Domains (6) summary
      PLN00192
      Location:1 → 1331
      PLN00192; aldehyde oxidase
      pfam00941
      Location:223 → 398
      FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
      pfam01315
      Location:579 → 689
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      pfam01799
      Location:84 → 162
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:718 → 1239
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:412 → 520
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

    6. NM_001336107.1 → NP_001324269.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZK7, A0A5S9X1K9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7G9P4.1

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