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    AtPOT1a Nucleic acid-binding, OB-fold-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815069, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AtPOT1a
    Official Full Name
    Nucleic acid-binding, OB-fold-like protein
    Primary source
    TAIR:AT2G05210
    Locus tag
    AT2G05210
    See related
    Araport:AT2G05210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPOT1; F5G3.11; F5G3_11; Protection of Telomeres 1a
    Summary
    Encodes AtPOT1a, an accessory factor for telomerase required for positive telomere length regulation. Note on nomenclature: different names have been given to Arabidopsis POT-like genes (Kuchar and Fajkus, 2004; Shakirov et al, 2005; Tani and Murata, 2005). According to a unifying nomenclature (Surovtseva et al, 2007), At2g05210 (previously named AtPOT1) is designated AtPOT1a, while At5g06310 (previously named AtPOT2) is designated AtPOT1b.
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    Genomic context

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    See AtPOT1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (1890684..1894514)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene Ribosomal S17 family protein Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. Surovtseva YV, et al. EMBO J, 2007 Aug 8. PMID 17627276, Free PMC Article
    2. Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly. Song J, et al. Nucleic Acids Res, 2021 Sep 20. PMID 34403479, Free PMC Article
    3. Evolution of Arabidopsis protection of telomeres 1 alters nucleic acid recognition and telomerase regulation. Arora A, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27651456, Free PMC Article
    4. POT1-independent single-strand telomeric DNA binding activities in Brassicaceae. Shakirov EV, et al. Plant J, 2009 Jun. PMID 19228335, Free PMC Article
    5. The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection. Shakirov EV, et al. Mol Cell Biol, 2005 Sep. PMID 16107718, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly.
      Title: Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly.
    2. POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.
      Title: POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.
    3. Our results reveal a molecular mechanism for the role of these positively selected sites in AtPOT1a.
      Title: Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction.
    4. Single-strand telomeric DNA binding activity present in A. thaliana nuclear extracts is not dependent on POT1a or POT1b proteins.
      Title: POT1-independent single-strand telomeric DNA binding activities in Brassicaceae.
    5. AtPot1 (protection of telomeres 1) and AtPot2 are ubiquitously expressed at low levels in Arabidopsis. AtPot1 is essential for telomere length maintenance. [Atpot1]
      Title: The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001124798.2
    NM_001124799.2
    NM_126547.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nucleic acid-binding, OB-fold-like protein
    NP_001118270.1
    • Protection of Telomeres 1a (AtPOT1a); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Telomere end binding protein (InterPro:IPR011564); BEST Arabidopsis thaliana protein match is: Nucleic acid-binding, OB-fold-like protein (TAIR:AT5G06310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001118271.1
    • Protection of Telomeres 1a (AtPOT1a); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Telomere end binding protein (InterPro:IPR011564); BEST Arabidopsis thaliana protein match is: Nucleic acid-binding, OB-fold-like protein (TAIR:AT5G06310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_178592.3
    • Protection of Telomeres 1a (AtPOT1a); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Telomere end binding protein (InterPro:IPR011564); BEST Arabidopsis thaliana protein match is: Nucleic acid-binding, OB-fold-like protein (TAIR:AT5G06310.1); Has 103 Blast hits to 102 proteins in 42 species: Archae - 0; Bacteria - 0; Metazoa - 19; Fungi - 4; Plants - 80; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1890684..1894514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001124798.2 → NP_001118270.1  Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4W6W9, Q4W6X0, Q52VR7, Q56Y52, Q6Q835, Q9SJ37
      UniProtKB/TrEMBL
      A0A7G2E7H9
      Conserved Domains (1) summary
      smart00976
      Location:11 → 145
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13

    2. NM_126547.5 → NP_178592.3  Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178592.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4W6W9, Q4W6X0, Q52VR7, Q56Y52, Q6Q835, Q9SJ37
      UniProtKB/TrEMBL
      A0A7G2E7H9
      Conserved Domains (1) summary
      smart00976
      Location:11 → 145
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13

    3. NM_001124799.2 → NP_001118271.1  Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4W6W9, Q4W6X0, Q52VR7, Q56Y52, Q6Q835, Q9SJ37
      UniProtKB/TrEMBL
      A0A7G2E7H9
      Conserved Domains (1) summary
      smart00976
      Location:11 → 145
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56Y52.1

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