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    CDPK2 calcium-dependent protein kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840471, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDPK2
    Official Full Name
    calcium-dependent protein kinase 2
    Primary source
    TAIR:AT1G35670
    Locus tag
    AT1G35670
    See related
    Araport:AT1G35670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCDPK2; ATCPK11; calcium-dependent protein kinase 2; CALCIUM-DEPENDENT PROTEIN KINASE 2; CPK11; F15O4.8
    Summary
    Encodes a Ca(2+)-dependent, calmodulin-independent protein kinase that is rapidly induced by drought and high-salt stress but not by low-temperature stress or heat stress. Positive regulator of ABA signaling. Phosphorylates ABA responsive transcription factors ABF1 and ABF4.
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    Genomic context

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    See CDPK2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (13205345..13208289)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene erythroid differentiation factor-like protein Neighboring gene pseudo Neighboring gene Ribosomal protein L21 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tobacco calcium-dependent protein kinases are differentially phosphorylated in vivo as part of a kinase cascade that regulates stress response. Witte CP, et al. J Biol Chem, 2010 Mar 26. PMID 20118232, Free PMC Article
    2. Two genes that encode Ca(2+)-dependent protein kinases are induced by drought and high-salt stresses in Arabidopsis thaliana. Urao T, et al. Mol Gen Genet, 1994 Aug 15. PMID 8078458
    3. Ca2+-dependent protein kinase11 and 24 modulate the activity of the inward rectifying K+ channels in Arabidopsis pollen tubes. Zhao LN, et al. Plant Cell, 2013 Feb. PMID 23449501, Free PMC Article
    4. Overexpression of the wheat salt tolerance-related gene TaSC enhances salt tolerance in Arabidopsis. Huang X, et al. J Exp Bot, 2012 Sep. PMID 22821939
    5. Abscisic acid inhibits root growth in Arabidopsis through ethylene biosynthesis. Luo X, et al. Plant J, 2014 Jul. PMID 24738778

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two abscisic acid (ABA)-activated calcium-dependent protein kinases, CPK4 and CPK11, phosphorylate the C-terminus of ACS6 and increase the stability of ACS6 in ethylene biosynthesis.
      Title: Abscisic acid inhibits root growth in Arabidopsis through ethylene biosynthesis.
    2. CPK11 and CPK24 together mediate the Ca(2+)-dependent inhibition of the inward rectifying K+ channels and participate in the regulation of pollen tube growth in Arabidopsis.
      Title: Ca2+-dependent protein kinase11 and 24 modulate the activity of the inward rectifying K+ channels in Arabidopsis pollen tubes.
    3. TaSC overexpression in Arabidopsis ecotype Columbia and AtSC knockout mutant (atsc)signi fi cantly up-regulated the expression of AtFRY1, AtSAD1, and AtCDPK2. AtCDPK2 overexpression in atsc rescued the salt-sensitive phenotype of atsc.
      Title: Overexpression of the wheat salt tolerance-related gene TaSC enhances salt tolerance in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103271.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calcium-dependent protein kinase 2
    NP_174807.1
    • calcium-dependent protein kinase 2 (CDPK2); FUNCTIONS IN: calmodulin-dependent protein kinase activity, kinase activity; INVOLVED IN: response to water deprivation, response to salt stress, protein amino acid phosphorylation, positive regulation of abscisic acid mediated signaling pathway; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium-dependent protein kinase 4 (TAIR:AT4G09570.1); Has 134131 Blast hits to 125244 proteins in 4234 species: Archae - 175; Bacteria - 14420; Metazoa - 49980; Fungi - 18055; Plants - 27559; Viruses - 606; Other Eukaryotes - 23336 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      13205345..13208289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103271.4 → NP_174807.1  calcium-dependent protein kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39016, Q949P0, Q9LQH7
      UniProtKB/TrEMBL
      A0A178W2R7
      Conserved Domains (4) summary
      PTZ00184
      Location:320 → 462
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:332 → 391
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd05117
      Location:25 → 283
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
      pfam00069
      Location:26 → 284
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39016.2

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