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    RSL4 root hair defective 6-like 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839667, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RSL4
    Official Full Name
    root hair defective 6-like 4
    Primary source
    TAIR:AT1G27740
    Locus tag
    AT1G27740
    See related
    Araport:AT1G27740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    root hair defective 6-like 4; T22C5.19; T22C5_19
    Summary
    Basic helix-loop-helix (bHLH) transcription factor that is sufficient to promote postmitotic cell growth in root-hair cells. RSL4 is a direct transcriptional target of RHD6
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    Genomic context

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    See RSL4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (9654475..9656089)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Glycine-rich protein family Neighboring gene TBP-associated factor 4B Neighboring gene salt tolerance zinc finger Neighboring gene nucleic acid binding protein Neighboring gene Ubiquitin system component Cue protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tracheophytes Contain Conserved Orthologs of a Basic Helix-Loop-Helix Transcription Factor That Modulate ROOT HAIR SPECIFIC Genes. Hwang Y, et al. Plant Cell, 2017 Jan. PMID 28087829, Free PMC Article
    2. ROOT HAIR DEFECTIVE SIX-LIKE4 (RSL4) promotes root hair elongation by transcriptionally regulating the expression of genes required for cell growth. Vijayakumar P, et al. New Phytol, 2016 Dec. PMID 27452638, Free PMC Article
    3. EIN3 and RSL4 interfere with an MYB-bHLH-WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis. Qiu Y, et al. Proc Natl Acad Sci U S A, 2021 Dec 21. PMID 34916289, Free PMC Article
    4. GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis. Shibata M, et al. Development, 2018 Feb 8. PMID 29439132, Free PMC Article
    5. A basic helix-loop-helix transcription factor controls cell growth and size in root hairs. Yi K, et al. Nat Genet, 2010 Mar. PMID 20139979

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EIN3 and RSL4 interfere with an MYB-bHLH-WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis.
      Title: EIN3 and RSL4 interfere with an MYB-bHLH-WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis.
    2. A trihelix transcription factor GT-2-LIKE1 (GTL1) and its homolog DF1 repress root hair growth. Transcriptional data, combined with genome-wide chromatin-binding data, show that GTL1 and DF1 directly bind the RSL4 promoter and regulate its expression to repress root hair growth.
      Title: GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis.
    3. RSL4 controls cell growth by controlling the expression of genes encoding proteins involved in cell signalling, cell wall modification and secretion.
      Title: ROOT HAIR DEFECTIVE SIX-LIKE4 (RSL4) promotes root hair elongation by transcriptionally regulating the expression of genes required for cell growth.
    4. Results suggest that RSL4 mediates root hair formation by regulating root hair-specific cis-element (RHE) genes and that this mechanism is conserved throughout the tracheophyte (vascular plant) lineage.
      Title: Tracheophytes Contain Conserved Orthologs of a Basic Helix-Loop-Helix Transcription Factor That Modulate ROOT HAIR SPECIFIC Genes.
    5. study reports the discovery of a basic helix-loop-helix (bHLH) transcription factor called RSL4 (ROOT HAIR DEFECTIVE 6-LIKE 4) that is sufficient to promote postmitotic cell growth in Arabidopsis thaliana root-hair cells
      Title: A basic helix-loop-helix transcription factor controls cell growth and size in root hairs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102539.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    root hair defective 6-like 4
    NP_564293.1
    • root hair defective 6-like 4 (RSL4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: root hair initiation, response to auxin stimulus, positive regulation of transcription, cell growth, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: trichoblast, root; EXPRESSED DURING: 5 root hair formation; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT5G43175.1); Has 2802 Blast hits to 2796 proteins in 105 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 24; Plants - 2776; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9654475..9656089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102539.3 → NP_564293.1  root hair defective 6-like 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564293.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A178WM21, C0SUX8, Q8LEG1, Q9SFY5
      UniProtKB/TrEMBL
      A0A384L1Z0
      Conserved Domains (1) summary
      cd11454
      Location:174 → 236
      bHLH_AtIND_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein INDEHISCENT (IND) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LEG1.1

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