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    UGT74F1 UDP-glycosyltransferase 74 F1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818988, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UGT74F1
    Official Full Name
    UDP-glycosyltransferase 74 F1
    Primary source
    TAIR:AT2G43840
    Locus tag
    AT2G43840
    See related
    Araport:AT2G43840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18O19.5; UDP-glycosyltransferase 74 F1
    Summary
    UGT74F1 transfers UDP:glucose to salicylic acid (forming a glucoside), benzoic acid, quercetin, and athranilate in vitro. UGT74F1 shows a weak ability to catalyze the formation of the p-aminobenzoate-glucose ester in vitro. But, UGT75B1 appears to be the dominant pABA acylglucosyltransferase in vivo based on assays in leaves, flowers, and siliques. The true biological substrate(s) of UGT74F1 are not known, but mutant plants lacking UGT74F1 have a decreased level of salicylate glucoside.
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    Genomic context

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    See UGT74F1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (18157529..18159231)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene UDP-glucosyltransferase 74F2 Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene Integrin-linked protein kinase family Neighboring gene Pectin lyase-like superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana. George Thompson AM, et al. Sci Rep, 2017 Apr 20. PMID 28425481, Free PMC Article
    2. Metabolism of salicylic acid in wild-type, ugt74f1 and ugt74f2 glucosyltransferase mutants of Arabidopsis thaliana. Dean JV, et al. Physiol Plant, 2008 Apr. PMID 18248508
    3. Metabolism of the folate precursor p-aminobenzoate in plants: glucose ester formation and vacuolar storage. Eudes A, et al. J Biol Chem, 2008 May 30. PMID 18385129, Free PMC Article
    4. The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates. Lim EK, et al. J Biol Chem, 2002 Jan 4. PMID 11641410
    5. Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides. Lim EK, et al. Biotechnol Bioeng, 2004 Sep 5. PMID 15352060

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_129946.3
    NM_201953.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-glucose:4-aminobenzoate acylglucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables benzoic acid glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavonol 7-O-beta-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables quercetin 4'-O-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables quercetin 7-O-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables salicylic acid glucosyltransferase (glucoside-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within benzoate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within para-aminobenzoic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within salicylic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glycosyltransferase 74 F1
    NP_181912.1
    • UDP-glycosyltransferase 74 F1 (UGT74F1); CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glucosyltransferase 74F2 (TAIR:AT2G43820.1); Has 8300 Blast hits to 8222 proteins in 540 species: Archae - 0; Bacteria - 767; Metazoa - 2272; Fungi - 26; Plants - 5053; Viruses - 115; Other Eukaryotes - 67 (source: NCBI BLink).
    NP_973682.1
    • UDP-glycosyltransferase 74 F1 (UGT74F1); CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glucosyltransferase 74F2 (TAIR:AT2G43820.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18157529..18159231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_201953.2 → NP_973682.1  UDP-glycosyltransferase 74 F1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F6V9, F4IS54
      Conserved Domains (1) summary
      PLN02173
      Location:1 → 449
      PLN02173; UDP-glucosyl transferase family protein

    2. NM_129946.3 → NP_181912.1  UDP-glycosyltransferase 74 F1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22820, Q56XT4
      UniProtKB/TrEMBL
      A0A178VQD2, A0A384LDG7, A0A654F6V9, W8Q6W5
      Conserved Domains (1) summary
      PLN02173
      Location:1 → 449
      PLN02173; UDP-glucosyl transferase family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22820.1

    Gene LinkOut

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