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    PP2AA3 protein phosphatase 2A subunit A3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837892, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PP2AA3
    Official Full Name
    protein phosphatase 2A subunit A3
    Primary source
    TAIR:AT1G13320
    Locus tag
    AT1G13320
    See related
    Araport:AT1G13320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    65 KDA REGULATORY SUBUNIT OF PROTEIN PHOSPHATASE 2A; PR65; protein phosphatase 2A subunit A3; protein phosphatase 2A subunit A3; T6J4.8; T6J4_8
    Summary
    one of three genes encoding the 65 kDa regulatory subunit of protein phosphatase 2A (PP2A)
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    Genomic context

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    See PP2AA3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (4563428..4567849, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene myb-like transcription factor family protein Neighboring gene Endosomal targeting BRO1-like domain-containing protein Neighboring gene Tat-binding protein 1(Tbp-1)-interacting protein (TBPIP) Neighboring gene Regulator of Vps4 activity in the MVB pathway protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of cDNA and genomic clones encoding homologues of the 65 kDa regulatory subunit of protein phosphatase 2A in Arabidopsis thaliana. Slabas AR, et al. Plant Mol Biol, 1994 Nov. PMID 7811971
    2. The Arabidopsis TONNEAU2 gene encodes a putative novel protein phosphatase 2A regulatory subunit essential for the control of the cortical cytoskeleton. Camilleri C, et al. Plant Cell, 2002 Apr. PMID 11971138, Free PMC Article
    3. Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3. Tran HT, et al. Plant J, 2012 Jul. PMID 22404109
    4. TIME FOR COFFEE represses accumulation of the MYC2 transcription factor to provide time-of-day regulation of jasmonate signaling in Arabidopsis. Shin J, et al. Plant Cell, 2012 Jun. PMID 22693280, Free PMC Article
    5. A PP6-type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis. Dai M, et al. Plant Cell, 2012 Jun. PMID 22715043, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035958.1
    NM_001198052.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane HDA PubMed 
    part_of protein phosphatase type 2A complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 2A subunit A3
    NP_001031035.1
    • protein phosphatase 2A subunit A3 (PP2AA3); FUNCTIONS IN: binding, protein phosphatase type 2A regulator activity; INVOLVED IN: regulation of phosphorylation; LOCATED IN: cell wall, plasma membrane, protein phosphatase type 2A complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A subunit A2 (TAIR:AT3G25800.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001184981.1
    • protein phosphatase 2A subunit A3 (PP2AA3); FUNCTIONS IN: binding, protein phosphatase type 2A regulator activity; INVOLVED IN: regulation of phosphorylation; LOCATED IN: protein phosphatase type 2A complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A subunit A2 (TAIR:AT3G25800.1).
    NP_172790.2
    • protein phosphatase 2A subunit A3 (PP2AA3); FUNCTIONS IN: binding, protein phosphatase type 2A regulator activity; INVOLVED IN: regulation of phosphorylation; LOCATED IN: cell wall, plasma membrane, protein phosphatase type 2A complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A subunit A2 (TAIR:AT3G25800.1); Has 2761 Blast hits to 1677 proteins in 248 species: Archae - 13; Bacteria - 63; Metazoa - 1436; Fungi - 398; Plants - 296; Viruses - 0; Other Eukaryotes - 555 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4563428..4567849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101203.5 → NP_172790.2  protein phosphatase 2A subunit A3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172790.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38951, Q8LPH9, Q9FX65
      Conserved Domains (4) summary
      COG1413
      Location:193 → 419
      HEAT; HEAT repeat [General function prediction only]
      pfam12755
      Location:220 → 300
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      pfam13646
      Location:356 → 461
      HEAT_2; HEAT repeats
      sd00044
      Location:243 → 267
      HEAT; HEAT repeat [structural motif]

    2. NM_001332065.1 → NP_001320387.1  protein phosphatase 2A subunit A3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AMM6

    3. NM_001198052.1 → NP_001184981.1  protein phosphatase 2A subunit A3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38951, Q8LPH9, Q9FX65
      Conserved Domains (4) summary
      COG1413
      Location:193 → 419
      HEAT; HEAT repeat [General function prediction only]
      pfam12755
      Location:220 → 300
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      pfam13646
      Location:356 → 461
      HEAT_2; HEAT repeats
      sd00044
      Location:243 → 267
      HEAT; HEAT repeat [structural motif]

    4. NM_001035958.1 → NP_001031035.1  protein phosphatase 2A subunit A3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4HQR5
      Conserved Domains (4) summary
      COG1413
      Location:193 → 419
      HEAT; HEAT repeat [General function prediction only]
      pfam12755
      Location:220 → 300
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      pfam13646
      Location:356 → 461
      HEAT_2; HEAT repeats
      sd00044
      Location:243 → 267
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38951.2

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