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    IQD1 IQ-domain 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820128, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IQD1
    Official Full Name
    IQ-domain 1
    Primary source
    TAIR:AT3G09710
    Locus tag
    AT3G09710
    See related
    Araport:AT3G09710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    IQ-domain 1
    Summary
    Ca(2+)-dependent calmodulin-binding protein. Targeted to the nucleus. Involved in glucosinolate metabolism in response to biotic challenge. Expressed in vascular tissue.
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    Genomic context

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    See IQD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (2976572..2979784, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene POLAR LOCALIZATION DURING ASYMMETRIC DIVISION AND protein Neighboring gene S1FA-like DNA-binding protein Neighboring gene syntaxin of plants 71 Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The emerging function of IQD proteins as scaffolds in cellular signaling and trafficking. Abel S, et al. Plant Signal Behav, 2013 Jun. PMID 23531692, Free PMC Article
    2. Genome-wide comparative analysis of the IQD gene families in Arabidopsis thaliana and Oryza sativa. Abel S, et al. BMC Evol Biol, 2005 Dec 20. PMID 16368012, Free PMC Article
    3. Arabidopsis IQD1, a novel calmodulin-binding nuclear protein, stimulates glucosinolate accumulation and plant defense. Levy M, et al. Plant J, 2005 Jul. PMID 15960618
    4. Arabidopsis calmodulin-binding protein IQ67-domain 1 localizes to microtubules and interacts with kinesin light chain-related protein-1. Bürstenbinder K, et al. J Biol Chem, 2013 Jan 18. PMID 23204523, Free PMC Article
    5. The IQD Family of Calmodulin-Binding Proteins Links Calcium Signaling to Microtubules, Membrane Subdomains, and the Nucleus. Bürstenbinder K, et al. Plant Physiol, 2017 Mar. PMID 28115582, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the 33 members of the calmodulin (CaM)-interacting plant-specific IQ67 DOMAIN (IQD) family proteins differentially localize, using green fluorescent protein (GFP)-tagged proteins, to multiple and distinct subcellular sites, including including microtubule (MT) arrays, plasma membrane subdomains, and nuclear compartments.
      Title: The IQD Family of Calmodulin-Binding Proteins Links Calcium Signaling to Microtubules, Membrane Subdomains, and the Nucleus.
    2. In vivo binding to calmodulin and kinesin light chain-related protein-1 suggests a Ca2+-regulated scaffolding function of IQD1 in kinesin motor-dependent transport of multiprotein complexes.
      Title: The emerging function of IQD proteins as scaffolds in cellular signaling and trafficking.
    3. IQD1 may act as a scaffold protein recruiting cargo to kinesin motors (KLCR1) for directional transport along microtubules.
      Title: Arabidopsis calmodulin-binding protein IQ67-domain 1 localizes to microtubules and interacts with kinesin light chain-related protein-1.
    4. IQD proteins link calcium signaling pathways to the regulation of gene expression.
      Title: Genome-wide comparative analysis of the IQD gene families in Arabidopsis thaliana and Oryza sativa.
    5. It was proposed that IQD1 to be novel nuclear factor that integrates intracellular Ca(2+) signals to fine-tune glucosinolate accumulation in response to biotic challenge.
      Title: Arabidopsis IQD1, a novel calmodulin-binding nuclear protein, stimulates glucosinolate accumulation and plant defense.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202919.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucosinolate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    IQ-domain 1
    NP_001189848.1
    • IQ-domain 1 (IQD1); FUNCTIONS IN: calmodulin binding; INVOLVED IN: glucosinolate biosynthetic process, defense response; LOCATED IN: nucleus; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: IQ-domain 2 (TAIR:AT5G03040.3).
    NP_187582.1
    • IQ-domain 1 (IQD1); CONTAINS InterPro DOMAIN/s: IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: IQ-domain 2 (TAIR:AT5G03040.3); Has 11754 Blast hits to 5662 proteins in 558 species: Archae - 6; Bacteria - 955; Metazoa - 3083; Fungi - 1479; Plants - 916; Viruses - 133; Other Eukaryotes - 5182 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2976572..2979784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111805.3 → NP_187582.1  IQ-domain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SF32
      UniProtKB/TrEMBL
      A0A178VJB4, A0A5S9XAN0
      Conserved Domains (2) summary
      smart00015
      Location:106 → 126
      IQ; Calmodulin-binding motif
      PTZ00108
      Location:273 → 438
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. NM_001202919.2 → NP_001189848.1  IQ-domain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VJB4, F4J1A4
      Conserved Domains (1) summary
      smart00015
      Location:106 → 126
      IQ; Calmodulin-binding motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SF32.1

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