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    IMPA-1 importin alpha isoform 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819857, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IMPA-1
    Official Full Name
    importin alpha isoform 1
    Primary source
    TAIR:AT3G06720
    Locus tag
    AT3G06720
    See related
    Araport:AT3G06720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AIMP ALPHA; AT-IMP; ATKAP ALPHA; IMPA1; IMPORTIN ALPHA; importin alpha isoform 1; IMPORTIN ALPHA ISOFORM 1
    Summary
    Encodes importin alpha involved in nuclear import. Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
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    Genomic context

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    See IMPA-1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (2120324..2124166)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ribosomal L29e protein family Neighboring gene E3 ubiquitin ligase Neighboring gene Thioredoxin z Neighboring gene GATA transcription factor 15 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha. He S, et al. PLoS One, 2011. PMID 21811563, Free PMC Article
    2. Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta. Hübner S, et al. J Biol Chem, 1999 Aug 6. PMID 10428841
    3. Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells. Petrovská B, et al. J Exp Bot, 2013 Nov. PMID 24006426, Free PMC Article
    4. Increasing plant susceptibility to Agrobacterium infection by overexpression of the Arabidopsis nuclear protein VIP1. Tzfira T, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12124400, Free PMC Article
    5. The VirE3 protein of Agrobacterium mimics a host cell function required for plant genetic transformation. Lacroix B, et al. EMBO J, 2005 Jan 26. PMID 15616576, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The LSD1-type zinc finger motifs of PsLSD1 are a novel nuclear localization signal and directly bind to importin alpha.
      Title: The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111552.3
    NM_180193.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    importin alpha isoform 1
    NP_187328.1
    • importin alpha isoform 1 (IMPA-1); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol, nuclear envelope, nucleolus, cell wall; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 2 (TAIR:AT4G16143.2); Has 4061 Blast hits to 2975 proteins in 282 species: Archae - 4; Bacteria - 22; Metazoa - 1539; Fungi - 665; Plants - 1109; Viruses - 0; Other Eukaryotes - 722 (source: NCBI BLink).
    NP_850524.1
    • AT-IMP; FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol, nuclear envelope, nucleolus, cell wall; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 2 (TAIR:AT4G16143.2); Has 4059 Blast hits to 2974 proteins in 281 species: Archae - 4; Bacteria - 22; Metazoa - 1537; Fungi - 665; Plants - 1109; Viruses - 0; Other Eukaryotes - 722 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2120324..2124166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111552.3 → NP_187328.1  importin alpha isoform 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187328.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49599, O81520, Q940R6, Q96321, Q9C841, Q9ZRI5
      UniProtKB/TrEMBL
      A0A178VHS3, A0A5S9XAD6
      Conserved Domains (2) summary
      COG5064
      Location:10 → 530
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:244 → 269
      ARM; armadillo repeat [structural motif]

    2. NM_180193.3 → NP_850524.1  importin alpha isoform 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850524.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49599, O81520, Q940R6, Q96321, Q9C841, Q9ZRI5
      UniProtKB/TrEMBL
      A0A178VHS3, A0A5S9XAD6
      Conserved Domains (2) summary
      COG5064
      Location:10 → 530
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:244 → 269
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96321.2

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