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    4CL2 4-coumarate:CoA ligase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821678, updated on 18-Sep-2024

    Summary

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    Official Symbol
    4CL2
    Official Full Name
    4-coumarate:CoA ligase 2
    Primary source
    TAIR:AT3G21240
    Locus tag
    AT3G21240
    See related
    Araport:AT3G21240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-COUMARATE:COA LIGASE; 4-coumarate:CoA ligase 2; AT4CL2
    Summary
    encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, 5-OH-ferulic acid and cinnamic acid. At4CL2 was unable to use sinapic acid as substrate.
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    Genomic context

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    See 4CL2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (7454269..7457404, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene MAP kinase kinase 5 Neighboring gene 4-coumarate:CoA ligase 5 Neighboring gene multidrug resistance-associated protein 6 Neighboring gene ncRNA Neighboring gene Glycolipid transfer protein (GLTP) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Four Isoforms of Arabidopsis 4-Coumarate:CoA Ligase Have Overlapping yet Distinct Roles in Phenylpropanoid Metabolism. Li Y, et al. Plant Physiol, 2015 Dec. PMID 26491147, Free PMC Article
    2. Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms. Ehlting J, et al. Plant J, 1999 Jul. PMID 10417722
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 4CL1 or 4CL2 is required for normal plant growth.
      Title: Four Isoforms of Arabidopsis 4-Coumarate:CoA Ligase Have Overlapping yet Distinct Roles in Phenylpropanoid Metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001338515.1
    NM_001338516.1
    NM_113019.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-coumarate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phenylpropanoid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    4-coumarate:CoA ligase 2
    NP_188761.1
    • 4-coumarate:CoA ligase 2 (4CL2); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 1 (TAIR:AT1G51680.1); Has 86092 Blast hits to 78635 proteins in 3758 species: Archae - 1209; Bacteria - 54193; Metazoa - 3597; Fungi - 4717; Plants - 2816; Viruses - 1; Other Eukaryotes - 19559 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7454269..7457404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113019.4 → NP_188761.1  4-coumarate:CoA ligase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53Z06, Q56ZS8, Q9LU35, Q9S725
      UniProtKB/TrEMBL
      A0A178VMQ7, B1GUZ3, B1GUZ8
      Conserved Domains (2) summary
      cd05904
      Location:32 → 546
      4CL; 4-Coumarate-CoA Ligase (4CL)
      PLN02246
      Location:14 → 553
      PLN02246; 4-coumarate--CoA ligase

    2. NM_001338515.1 → NP_001327049.1  4-coumarate:CoA ligase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VMQ7, A0A1I9LR43, B1GUZ8

    3. NM_001338516.1 → NP_001327048.1  4-coumarate:CoA ligase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VMQ7, A0A1I9LR43, B1GUZ8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S725.2

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