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    ACT2 actin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821411, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACT2
    Official Full Name
    actin 2
    Primary source
    TAIR:AT3G18780
    Locus tag
    AT3G18780
    See related
    Araport:AT3G18780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    actin 2; DEFORMED ROOT HAIRS 1; DER1; ENHANCER OF LRX1 2; ENL2; FIZ2; FRIZZY AND KINKED SHOOTS 2; LIGHT STRESS-REGULATED 2; LSR2
    Summary
    Encodes an actin that is constitutively expressed in vegetative structures but not pollen. ACT2 is involved in tip growth of root hairs.
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    Genomic context

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    See ACT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (6474710..6477204)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene pre-mRNA-splicing factor ISY1-like protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-point ACT2 gene mutation in the Arabidopsis root hair mutant der1-3 affects overall actin organization, root growth and plant development. Vaškebová L, et al. Ann Bot, 2018 Nov 3. PMID 29293922, Free PMC Article
    2. Single Amino Acid Exchange in ACTIN2 Confers Increased Tolerance to Oxidative Stress in Arabidopsis der1-3 Mutant. Kuběnová L, et al. Int J Mol Sci, 2021 Feb 13. PMID 33668638, Free PMC Article
    3. Arabidopsis vegetative actin isoforms, AtACT2 and AtACT7, generate distinct filament arrays in living plant cells. Kijima ST, et al. Sci Rep, 2018 Mar 12. PMID 29531328, Free PMC Article
    4. Functional nonequivalency of actin isovariants in Arabidopsis. Kandasamy MK, et al. Mol Biol Cell, 2002 Jan. PMID 11809837, Free PMC Article
    5. Both vegetative and reproductive actin isovariants complement the stunted root hair phenotype of the Arabidopsis act2-1 mutation. Gilliland LU, et al. Plant Physiol, 2002 Dec. PMID 12481103, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single Amino Acid Exchange in ACTIN2 Confers Increased Tolerance to Oxidative Stress in Arabidopsis der1-3 Mutant.
      Title: Single Amino Acid Exchange in ACTIN2 Confers Increased Tolerance to Oxidative Stress in Arabidopsis der1-3 Mutant.
    2. different actin isoforms (ACT2 and ACT7) are capable of constructing unique filament arrays, depending on the cell type or tissue.
      Title: Arabidopsis vegetative actin isoforms, AtACT2 and AtACT7, generate distinct filament arrays in living plant cells.
    3. The results suggest that the der1-3 mutation in the ACT2 gene does not influence solely root hair formation process, but also has more general effects on the actin cytoskeleton, plant growth and development.
      Title: Single-point ACT2 gene mutation in the Arabidopsis root hair mutant der1-3 affects overall actin organization, root growth and plant development.
    4. The alternatively spliced 5' domain of NDC1 strongly influences the expression of the functionally unrelated ACTIN2, which is a common reference gene in Arabidopsis thaliana for quantitative RT-PCR.
      Title: An alternatively spliced domain of the NDC1 NAD(P)H dehydrogenase gene strongly influences the expression of the ACTIN2 reference gene in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338358.1
    NM_001338359.1
    NM_112764.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cytokinin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to high light intensity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell tip growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    actin 2
    NP_001319585.1
    • actin 2 (ACT2); FUNCTIONS IN: structural constituent of cytoskeleton; INVOLVED IN: in 7 processes; LOCATED IN: nucleus, membrane, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Actin, conserved site (InterPro:IPR004001), Actin/actin-like (InterPro:IPR004000), Actin/actin-like conserved site (InterPro:IPR020902); BEST Arabidopsis thaliana protein match is: actin 8 (TAIR:AT1G49240.1); Has 14997 Blast hits to 14643 proteins in 3016 species: Archae - 6; Bacteria - 12; Metazoa - 5603; Fungi - 5165; Plants - 1589; Viruses - 2; Other Eukaryotes - 2620 (source: NCBI BLink).
    NP_188508.1
    • actin 2 (ACT2); FUNCTIONS IN: structural constituent of cytoskeleton; INVOLVED IN: in 7 processes; LOCATED IN: nucleus, membrane, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Actin, conserved site (InterPro:IPR004001), Actin/actin-like (InterPro:IPR004000), Actin/actin-like conserved site (InterPro:IPR020902); BEST Arabidopsis thaliana protein match is: actin 8 (TAIR:AT1G49240.1); Has 15142 Blast hits to 14749 proteins in 3039 species: Archae - 6; Bacteria - 12; Metazoa - 5705; Fungi - 5217; Plants - 1599; Viruses - 2; Other Eukaryotes - 2601 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6474710..6477204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112764.4 → NP_188508.1  actin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42056, Q96292
      UniProtKB/TrEMBL
      A0A178VJY0, A0A384KW03, B9DHA3, Q0WL95
      Conserved Domains (1) summary
      cl17037
      Location:3 → 377
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_001338358.1 → NP_001319585.1  actin 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9DHA3, F4J8V9

    3. NM_001338359.1 → NP_001327851.1  actin 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42056, Q96292
      UniProtKB/TrEMBL
      A0A178VJY0, A0A384KW03, B9DHA3, Q0WL95
      Conserved Domains (1) summary
      cl17037
      Location:3 → 377
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96292.1

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