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    POK2 phragmoplast orienting kinesin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821439, updated on 18-Sep-2024

    Summary

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    Official Symbol
    POK2
    Official Full Name
    phragmoplast orienting kinesin 2
    Primary source
    TAIR:AT3G19050
    Locus tag
    AT3G19050
    See related
    Araport:AT3G19050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    phragmoplast orienting kinesin 2
    Summary
    PHRAGMOPLAST ORIENTING KINESIN 2 is one of the two Arabidopsis homologs isolated in yeast two-hybrid screen for interaction partners of maize gene TANGLED1 (TAN1). Based on sequence homology in their motor domains, POK1 and POK2 belong to the kinesin-12 class which also includes the well-characterized group of phragmoplast-associated kinesins AtPAKRPs. Both kinesins are composed of an N-terminal motor domain throughout the entire C terminus and putative cargo binding tail domains. The expression domains for POK2 constructs were broader than those for POK1; both are expressed in tissues enriched for dividing cells. The phenotype of pok1/pok2 double mutants strongly resembles that of maize tan1 mutants, characterized by misoriented mitotic cytoskeletal arrays and misplaced cell walls.
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    Genomic context

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    See POK2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    37
    Sequence:
    Chromosome: 3; NC_003074.8 (6577724..6590253)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase of the TAFII250 family 2 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Homeodomain-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phragmoplast Orienting Kinesin 2 Is a Weak Motor Switching between Processive and Diffusive Modes. Chugh M, et al. Biophys J, 2018 Jul 17. PMID 30021112, Free PMC Article
    2. Dual localized kinesin-12 POK2 plays multiple roles during cell division and interacts with MAP65-3. Herrmann A, et al. EMBO Rep, 2018 Sep. PMID 30002118, Free PMC Article
    3. Two kinesins are involved in the spatial control of cytokinesis in Arabidopsis thaliana. Müller S, et al. Curr Biol, 2006 May 9. PMID 16682350
    4. RanGAP1 is a continuous marker of the Arabidopsis cell division plane. Xu XM, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 19011093, Free PMC Article
    5. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phragmoplast Orienting Kinesin 2 Is a Weak Motor Switching between Processive and Diffusive Modes
      Title: Phragmoplast Orienting Kinesin 2 Is a Weak Motor Switching between Processive and Diffusive Modes.
    2. these results suggest that dual localized POK2 plays multiple roles during plant cell division. POK2 likely stabilizes the phragmoplast midzone via interaction with the conserved microtubule-associated protein MAP65-3/PLEIADE, a well-established microtubule cross-linker.
      Title: Dual localized kinesin-12 POK2 plays multiple roles during cell division and interacts with MAP65-3.
    3. POK1 and POK2 participate in the spatial control of cytokinesis, perhaps via an interaction with the Arabidopsis TAN1 homolog, ATN. [POK2]
      Title: Two kinesins are involved in the spatial control of cytokinesis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112791.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinesis by cell plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phragmoplast microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phragmoplast orienting kinesin 2
    NP_188535.4
    • phragmoplast orienting kinesin 2 (POK2); FUNCTIONS IN: microtubule motor activity, ATP binding; INVOLVED IN: cytokinesis; EXPRESSED IN: root vascular system, primary root tip, lateral root primordium; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: phragmoplast orienting kinesin 1 (TAIR:AT3G17360.1); Has 204267 Blast hits to 80386 proteins in 3219 species: Archae - 3327; Bacteria - 35963; Metazoa - 90351; Fungi - 17822; Plants - 12667; Viruses - 746; Other Eukaryotes - 43391 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6577724..6590253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112791.6 → NP_188535.4  phragmoplast orienting kinesin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188535.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27IK6, Q9LJ60
      UniProtKB/TrEMBL
      A0A178VJB1, A0A654FDW9
      Conserved Domains (5) summary
      PLN03188
      Location:614 → 763
      PLN03188; kinesin-12 family protein; Provisional
      COG0419
      Location:2119 → 2676
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2077 → 2393
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1674 → 2384
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl22853
      Location:192 → 540
      Motor_domain; Myosin and Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27IK6.1

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