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    HAF2 histone acetyltransferase of the TAFII250 family 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821437, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAF2
    Official Full Name
    histone acetyltransferase of the TAFII250 family 2
    Primary source
    TAIR:AT3G19040
    Locus tag
    AT3G19040
    See related
    Araport:AT3G19040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    histone acetyltransferase of the TAFII250 family 2; TAF1; TAF1B; TBP-ASSOCIATED FACTOR 1; TBP-ASSOCIATED FACTOR 1B
    Summary
    Encodes a protein similar to TATA-binding protein-associated factor TAF1 (a.k.a. TAFII250) with histone acetyltransferase activity. It is required in integrating light signals to regulate gene expression and growth.
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    Genomic context

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    See HAF2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Sequence:
    Chromosome: 3; NC_003074.8 (6567021..6575613, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene transcription initiation factor TFIID subunit 1b-like protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene phragmoplast orienting kinesin 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HAF2 protein shapes histone acetylation levels of PRR5 and LUX loci in Arabidopsis. Lee K, et al. Planta, 2018 Aug. PMID 29789923
    2. Arabidopsis HAF2 gene encoding TATA-binding protein (TBP)-associated factor TAF1, is required to integrate light signals to regulate gene expression and growth. Bertrand C, et al. J Biol Chem, 2005 Jan 14. PMID 15525647
    3. Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte. Waterworth WM, et al. Plant J, 2015 Nov. PMID 26358508, Free PMC Article
    4. Arabidopsis GCN5, HD1, and TAF1/HAF2 interact to regulate histone acetylation required for light-responsive gene expression. Benhamed M, et al. Plant Cell, 2006 Nov. PMID 17085686, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The midday-activated HAF2 protein stimulates H3 acetylation (H3ac) deposition at the PRR5 and LUX loci, contributing to establishment of the raising phase.
      Title: The HAF2 protein shapes histone acetylation levels of PRR5 and LUX loci in Arabidopsis.
    2. A specific role for TAF1 in plant DNA repair processes and in plant resistance to genotoxic stress.TAF1 interaction with MRE11 is mediated by the C-terminal bromodomain of TAF1.
      Title: Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte.
    3. These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
      Title: Arabidopsis GCN5, HD1, and TAF1/HAF2 interact to regulate histone acetylation required for light-responsive gene expression.
    4. the Arabidopsis HAF2 gene functions as a coactivator capable of integrating light signals and acetylating histones to activate light-induced gene transcription [HAF2]
      Title: Arabidopsis HAF2 gene encoding TATA-binding protein (TBP)-associated factor TAF1, is required to integrate light signals to regulate gene expression and growth.
    Submit: New GeneRIF Correction

    General gene information

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    NM_112790.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase of the TAFII250 family 2
    NP_188534.2
    • histone acetyltransferase of the TAFII250 family 2 (HAF2); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity, DNA binding; INVOLVED IN: histone acetylation, response to light stimulus; LOCATED IN: membrane, transcription factor TFIID complex; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), Bromodomain, conserved site (InterPro:IPR018359), Bromodomain (InterPro:IPR001487); BEST Arabidopsis thaliana protein match is: HAC13 protein (HAC13) (TAIR:AT1G32750.1); Has 14836 Blast hits to 8275 proteins in 670 species: Archae - 0; Bacteria - 64; Metazoa - 6564; Fungi - 2006; Plants - 2354; Viruses - 152; Other Eukaryotes - 3696 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6567021..6575613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338377.1 → NP_001327580.1  histone acetyltransferase of the TAFII250 family 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VFF6, A0A1I9LSR7

    2. NM_112790.3 → NP_188534.2  histone acetyltransferase of the TAFII250 family 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188534.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6PUA2, Q9LJ62
      UniProtKB/TrEMBL
      A0A178VFF6
      Conserved Domains (5) summary
      smart00213
      Location:574 → 644
      UBQ; Ubiquitin homologues
      pfam12157
      Location:491 → 1052
      DUF3591; Protein of unknown function (DUF3591)
      pfam15452
      Location:1352 → 1464
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      cl00155
      Location:574 → 646
      UBQ; Ubiquitin-like proteins
      cl02556
      Location:1665 → 1778
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PUA2.1

    Gene LinkOut

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