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    TL29 ascorbate peroxidase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826480, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TL29
    Official Full Name
    ascorbate peroxidase 4
    Primary source
    TAIR:AT4G09010
    Locus tag
    AT4G09010
    See related
    Araport:AT4G09010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    APX4; ascorbate peroxidase 4; F23J3.40; F23J3_40; thylakoid lumen 29
    Summary
    Encodes a thylakoid lumen protein that was initially believed to act as a microsomal ascorbate peroxidase APX4 but to date, no evidence of enzymatic activity has been found.
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    Genomic context

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    See TL29 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (5777397..5779572, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene general regulatory factor 1 Neighboring gene ncRNA Neighboring gene Mitochondrial ribosomal protein L27 Neighboring gene isoamylase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The APX4 locus regulates seed vigor and seedling growth in Arabidopsis thaliana. Wang YY, et al. Planta, 2014 Apr. PMID 24407512
    2. Crystal structure of the TL29 protein from Arabidopsis thaliana: an APX homolog without peroxidase activity. Lundberg E, et al. J Struct Biol, 2011 Oct. PMID 21798352
    3. The TL29 protein is lumen located, associated with PSII and not an ascorbate peroxidase. Granlund I, et al. Plant Cell Physiol, 2009 Nov. PMID 19828564
    4. Characterization of the Free and Membrane-Associated Fractions of the Thylakoid Lumen Proteome in Arabidopsis thaliana. Gollan PJ, et al. Int J Mol Sci, 2021 Jul 29. PMID 34360890, Free PMC Article
    5. Thioredoxin targets of the plant chloroplast lumen and their implications for plastid function. Hall M, et al. Proteomics, 2010 Mar. PMID 20049866

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APX4 is involved in the reactive oxygen species (ROS)-scavenging process in chloroplasts.
      Title: The APX4 locus regulates seed vigor and seedling growth in Arabidopsis thaliana.
    2. Crystal structure of the TL29 protein from Arabidopsis thaliana: an APX homolog without peroxidase activity
      Title: Crystal structure of the TL29 protein from Arabidopsis thaliana: an APX homolog without peroxidase activity.
    3. TL29 protein is a lumen-located subunit associated with PSII and not a peroxidase involved in reactive oxygen species stress response. [TL29]
      Title: The TL29 protein is lumen located, associated with PSII and not an ascorbate peroxidase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001340606.1
    NM_001340607.1
    NM_116970.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables L-ascorbate peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid lumen HDA PubMed 
    located_in chloroplast thylakoid lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in thylakoid HDA PubMed 
    located_in thylakoid lumen HDA PubMed 

    General protein information

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    Preferred Names
    ascorbate peroxidase 4
    NP_192640.1
    • ascorbate peroxidase 4 (APX4); FUNCTIONS IN: peroxidase activity, heme binding; INVOLVED IN: oxidation reduction, response to oxidative stress; LOCATED IN: in 7 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 5 (TAIR:AT4G35970.1); Has 1182 Blast hits to 1180 proteins in 264 species: Archae - 20; Bacteria - 119; Metazoa - 0; Fungi - 348; Plants - 604; Viruses - 0; Other Eukaryotes - 91 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      5777397..5779572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116970.3 → NP_192640.1  ascorbate peroxidase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P82281, Q7XZP6, Q9M0S6
      UniProtKB/TrEMBL
      A0A178UTM3, A0A5S9XSG0
      Conserved Domains (1) summary
      cd00314
      Location:96 → 274
      plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases

    2. NM_001340607.1 → NP_001329836.1  ascorbate peroxidase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UTM3, A0A1P8B8Y3

    3. NM_001340606.1 → NP_001329837.1  ascorbate peroxidase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UTM3, A0A1P8B8W6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82281.2

    Gene LinkOut

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