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    APG8A Ubiquitin-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828287, updated on 18-Sep-2024

    Summary

    Official Symbol
    APG8A
    Official Full Name
    Ubiquitin-like superfamily protein
    Primary source
    TAIR:AT4G21980
    Locus tag
    AT4G21980
    See related
    Araport:AT4G21980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATG8A; AUTOPHAGY 8A; AUTOPHAGY-RELATED 8A; F1N20.80; F1N20_80
    Summary
    Encodes APG8, a component of autophagy conjugation pathway. Delivered to the lumens of vacuole under nitrogen-starvation condition. Highest expression in flowers. mRNA abundance increased during dark-induced carbon starvation. Predominantly cytoplasmic with or without N starvation. Upon concanamycin A the protein accumulates in the central vacuole as punctuate structures that resemble autophagic bodies. This localization is more abundant upon N starvation.
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    Genomic context

    See APG8A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (11655562..11657034)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Peroxidase superfamily protein Neighboring gene senescence regulator (Protein of unknown function, DUF584) Neighboring gene APS reductase 3 Neighboring gene tyrosine sulfotransferase-like protein Neighboring gene SKU5 similar 4

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    NM_001084955.1
    NM_118319.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Atg8 activating enzyme activity PubMed 
    enables Atg8-family ligase activity PubMed 
    enables protein binding PubMed 
    enables protein-phosphatidylethanolamide deconjugating activity PubMed 
    Component Evidence Code Pubs
    located_in autophagosome PubMed 
    located_in autophagosome PubMed 
    located_in chloroplast  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in phagophore PubMed 
    located_in vacuolar lumen  

    General protein information

    Preferred Names
    Ubiquitin-like superfamily protein
    NP_001078424.1
    • AUTOPHAGY 8A (APG8A); FUNCTIONS IN: APG8-specific protease activity, APG8 activating enzyme activity, Atg8 ligase activity; INVOLVED IN: autophagy; LOCATED IN: vacuolar lumen, autophagic vacuole, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Light chain 3 (LC3) (InterPro:IPR004241); BEST Arabidopsis thaliana protein match is: Ubiquitin-like superfamily protein (TAIR:AT4G04620.2); Has 1531 Blast hits to 1529 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 726; Fungi - 172; Plants - 305; Viruses - 3; Other Eukaryotes - 325 (source: NCBI BLink).
    NP_567642.1
    • AUTOPHAGY 8A (APG8A); CONTAINS InterPro DOMAIN/s: Light chain 3 (LC3) (InterPro:IPR004241); BEST Arabidopsis thaliana protein match is: Ubiquitin-like superfamily protein (TAIR:AT4G04620.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11655562..11657034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118319.4 → NP_567642.1  Ubiquitin-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567642.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65447, Q8LEM4, Q8S928
      UniProtKB/TrEMBL
      A0A178UVA3, A0A5S9XVI8
      Conserved Domains (1) summary
      cd16128
      Location:12 → 114
      Ubl_ATG8; ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae Atg8p and related proteins; sub-family of the autophagy-related 8 (ATG8) family
    2. NM_001084955.1 → NP_001078424.1  Ubiquitin-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MS84
      Conserved Domains (1) summary
      cd01611
      Location:21 → 132
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein
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