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    MUS308 and mammalian DNA polymerase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829406, updated on 18-Sep-2024

    Summary

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    Official Full Name
    MUS308 and mammalian DNA polymerase-like protein
    Primary source
    TAIR:AT4G32700
    Locus tag
    AT4G32700
    See related
    Araport:AT4G32700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    Encodes a homolog of Drosophila MUS308 and mammalian DNA polymerase, which prevent spontaneous or DNA damage-induced production of DNA double strand breaks. Two conserved functional domains: an N-terminal superfamily II DNA/RNA helicase domain and a C-terminal prokaryotic-type DNA polymerase I domain. Required for regulated cell division and differentiation in meristems. Mutant plants show morphological defects, such as short roots, serrated leaves, and fasciation, as well as defective patterns of cell division and differentiation in the meristem. Mutant plants had 2.5 to 4.5-fold higher expression of ATGR1, ATBRCA1 and RAD51 genes. TEB is required for normal progression of DNA replication and for correct expression of genes during development.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    26
    Sequence:
    Chromosome: 4; NC_003075.7 (15767185..15779697)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene uncharacterized protein Neighboring gene hemoglobin 3 Neighboring gene Protein kinase superfamily protein Neighboring gene SCR-like 25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. T-DNA integration in plants results from polymerase-θ-mediated DNA repair. van Kregten M, et al. Nat Plants, 2016 Oct 31. PMID 27797358
    2. A link among DNA replication, recombination, and gene expression revealed by genetic and genomic analysis of TEBICHI gene of Arabidopsis thaliana. Inagaki S, et al. PLoS Genet, 2009 Aug. PMID 19696887, Free PMC Article
    3. The plant DNA polymerase theta is essential for the repair of replication-associated DNA damage. Nisa M, et al. Plant J, 2021 Jun. PMID 33989439
    4. Arabidopsis TEBICHI, with helicase and DNA polymerase domains, is required for regulated cell division and differentiation in meristems. Inagaki S, et al. Plant Cell, 2006 Apr. PMID 16517762, Free PMC Article
    5. Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nair DT, et al. Nat Struct Mol Biol, 2006 Jul. PMID 16819516

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The plant DNA polymerase theta is essential for the repair of replication-associated DNA damage.
      Title: The plant DNA polymerase theta is essential for the repair of replication-associated DNA damage.
    2. Pol theta provides the mechanism for T-DNA random integration into the plant genome, demonstrating a potential to disrupt random integration so as to improve the quality and biosafety of plant transgenesis. [Pol theta]
      Title: T-DNA integration in plants results from polymerase-θ-mediated DNA repair.
    3. TEBICHI is required for normal progression of DNA replication and for correct expression of genes during development. [TEBICHI]
      Title: A link among DNA replication, recombination, and gene expression revealed by genetic and genomic analysis of TEBICHI gene of Arabidopsis thaliana.
    4. 1,N6-ethenodeoxyadenosine attaches to the active ssiteand presents its 'Hoogsteen edge' for hydrogen-bonding with incoming dTTP or dCTP.
      Title: Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001085013.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrachromosomal DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of adaxial/abaxial pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle G2/M phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MUS308 and mammalian DNA polymerase-like protein
    NP_001078482.1
    • helicases;ATP-dependent helicases;nucleic acid binding;ATP binding;DNA-directed DNA polymerases;DNA binding; FUNCTIONS IN: in 6 functions; INVOLVED IN: regulation of gene expression, DNA replication, DNA recombination, photomorphogenesis; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA-directed DNA polymerase, family A, palm domain (InterPro:IPR001098), DNA/RNA helicase, C-terminal (InterPro:IPR001650), DNA polymerase A domain (InterPro:IPR002298), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: U5 small nuclear ribonucleoprotein helicase (TAIR:AT2G42270.1); Has 17628 Blast hits to 16579 proteins in 2941 species: Archae - 600; Bacteria - 7507; Metazoa - 1254; Fungi - 1190; Plants - 590; Viruses - 412; Other Eukaryotes - 6075 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15767185..15779697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085013.2 → NP_001078482.1  MUS308 and mammalian DNA polymerase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65531, Q588V7
      UniProtKB/TrEMBL
      A0A5S9XY37, A0A654FV74
      Conserved Domains (4) summary
      cd08638
      Location:1724 → 2148
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      COG1204
      Location:499 → 1260
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18026
      Location:499 → 720
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
      cl10012
      Location:1679 → 1719
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q588V7.1

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