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    CST Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829712, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CST
    Official Full Name
    Protein kinase superfamily protein
    Primary source
    TAIR:AT4G35600
    Locus tag
    AT4G35600
    See related
    Araport:AT4G35600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CAST AWAY; CONNEXIN 32; CX32; F8D20.110; F8D20_110; Kin4; kinase 4
    Summary
    Encodes a receptor-like cytoplasmic kinase that acts as a spatial inhibitor of cell separation. Analysis of the cDNA previously described in Meiners et al., 1991 revealed mistakes in the predicted open reading frame.
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    Genomic context

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    See CST in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (16896153..16898933)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene RWP-RK domain-containing protein Neighboring gene zinc finger (C2H2 type) family protein Neighboring gene Cyclin B2;2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CAST AWAY, a membrane-associated receptor-like kinase, inhibits organ abscission in Arabidopsis. Burr CA, et al. Plant Physiol, 2011 Aug. PMID 21628627, Free PMC Article
    2. Protein N-acylation overrides differing targeting signals. Stael S, et al. FEBS Lett, 2011 Feb 4. PMID 21219905, Free PMC Article
    3. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
    4. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
    5. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203999.1
    NM_119725.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of floral organ abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_001190928.1
    • CONNEXIN 32; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT2G17220.2).
    NP_195285.3
    • CONNEXIN 32; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, N-terminal protein myristoylation; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT2G17220.2); Has 113047 Blast hits to 111623 proteins in 3982 species: Archae - 93; Bacteria - 12910; Metazoa - 41769; Fungi - 9485; Plants - 32138; Viruses - 364; Other Eukaryotes - 16288 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16896153..16898933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119725.5 → NP_195285.3  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195285.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81792, P27450, Q8VZ07, Q9M068
      UniProtKB/TrEMBL
      A0A178UXN4, A0A5S9XYW3
      Conserved Domains (1) summary
      cd14066
      Location:92 → 368
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs

    2. NM_001203999.1 → NP_001190928.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JN38
      Conserved Domains (2) summary
      smart00221
      Location:90 → 366
      STYKc; Protein kinase; unclassified specificity
      cd14066
      Location:93 → 369
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27450.2

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