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    KAI2 alpha/beta-Hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829902, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAI2
    Official Full Name
    alpha/beta-Hydrolases superfamily protein
    Primary source
    TAIR:AT4G37470
    Locus tag
    AT4G37470
    See related
    Araport:AT4G37470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6G17.120; F6G17_120; KARRIKIN INSENSITIVE 2
    Summary
    HTL belonging to the alpha/beta fold hydrolase superfamily. Mutant and over-expression studies indicates its involvement in seedling de-etiolation process.
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    Genomic context

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    See KAI2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (17616659..17618656, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene arabinogalactan protein 18 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene uncharacterized protein Neighboring gene CYCLIN B1;1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Karrikin Receptor Karrikin Insensitive2 Positively Regulates Heat Stress Tolerance in Arabidopsis thaliana. Abdelrahman M, et al. Plant Cell Physiol, 2023 Jan 30. PMID 35880749
    2. Specialisation within the DWARF14 protein family confers distinct responses to karrikins and strigolactones in Arabidopsis. Waters MT, et al. Development, 2012 Apr. PMID 22357928
    3. Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis. Guo Y, et al. Proc Natl Acad Sci U S A, 2013 May 14. PMID 23613584, Free PMC Article
    4. PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasitic plants. Conn CE, et al. Science, 2015 Jul 31. PMID 26228149
    5. A missense allele of KARRIKIN-INSENSITIVE2 impairs ligand-binding and downstream signaling in Arabidopsis thaliana. Lee I, et al. J Exp Bot, 2018 Jun 27. PMID 29722815, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Karrikin Receptor KAI2 Coordinates Salt Tolerance Mechanisms in Arabidopsis thaliana.
      Title: Karrikin Receptor KAI2 Coordinates Salt Tolerance Mechanisms in Arabidopsis thaliana.
    2. The Karrikin Receptor Karrikin Insensitive2 Positively Regulates Heat Stress Tolerance in Arabidopsis thaliana.
      Title: The Karrikin Receptor Karrikin Insensitive2 Positively Regulates Heat Stress Tolerance in Arabidopsis thaliana.
    3. Structure-Function Analysis of SMAX1 Reveals Domains That Mediate Its Karrikin-Induced Proteolysis and Interaction with the Receptor KAI2.
      Title: Structure-Function Analysis of SMAX1 Reveals Domains That Mediate Its Karrikin-Induced Proteolysis and Interaction with the Receptor KAI2.
    4. Comparative functional analyses of DWARF14 and KARRIKIN INSENSITIVE 2 in drought adaptation of Arabidopsis thaliana.
      Title: Comparative functional analyses of DWARF14 and KARRIKIN INSENSITIVE 2 in drought adaptation of Arabidopsis thaliana.
    5. Study demonstrated that majority of the effects on Arabidopsis root development previously attributed to strigolactones signaling are actually mediated by the KAI2 signaling pathway and all effects of KAI2 in the root can be explained by canonical SMAX1/SMXL2 activity. Results demonstrated that the KAI2 signaling pathway is an important new regulator of root hair and root development in Arabidopsis.
      Title: SMAX1/SMXL2 regulate root and root hair development downstream of KAI2-mediated signalling in Arabidopsis.
    6. Molecular and biochemical analyses revealed that the mutant KAI2ply2 protein is impaired in its ligand-binding activity.
      Title: A missense allele of KARRIKIN-INSENSITIVE2 impairs ligand-binding and downstream signaling in Arabidopsis thaliana.
    7. the karrikin-KAI2 signalling system can protect against abiotic stress, first by providing stress tolerance, and second by inhibiting germination under conditions unfavourable to seedling establishment.
      Title: Karrikin-KAI2 signalling provides Arabidopsis seeds with tolerance to abiotic stress and inhibits germination under conditions unfavourable to seedling establishment.
    8. allelic series decouples ligand hydrolysis and receptor degradation from downstream signalling
      Title: An allelic series at the KARRIKIN INSENSITIVE 2 locus of Arabidopsis thaliana decouples ligand hydrolysis and receptor degradation from downstream signalling.
    9. KAI2 degradation is independent of MAX2 and is not proteasome mediated.
      Title: Substrate-Induced Degradation of the α/β-Fold Hydrolase KARRIKIN INSENSITIVE2 Requires a Functional Catalytic Triad but Is Independent of MAX2.
    10. KAI2 and MAX2 define a regulatory pathway that largely operates independently of HY5 to mediate seedling responses to abiotic signals such as smoke and light.[KAI2]
      Title: KAI2- and MAX2-mediated responses to karrikins and strigolactones are largely independent of HY5 in Arabidopsis seedlings.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119911.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tag activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within de-etiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to karrikin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    alpha/beta-Hydrolases superfamily protein
    NP_195463.1
    • alpha/beta-Hydrolases superfamily protein; CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G03990.1); Has 8593 Blast hits to 8591 proteins in 1653 species: Archae - 86; Bacteria - 6869; Metazoa - 120; Fungi - 103; Plants - 302; Viruses - 19; Other Eukaryotes - 1094 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17616659..17618656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119911.4 → NP_195463.1  alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195463.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SZU7
      UniProtKB/TrEMBL
      A0A178V1E5, A0A5S9Y0C1
      Conserved Domains (1) summary
      COG0596
      Location:14 → 266
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZU7.1

    Gene LinkOut

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