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    NEK6 serine/threonine-protein kinase NEK5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823542, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NEK6
    Official Full Name
    serine/threonine-protein kinase NEK5
    Primary source
    TAIR:AT3G44200
    Locus tag
    AT3G44200
    See related
    Araport:AT3G44200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''NIMA (never in mitosis; ATNEK6; gene A)-related 6; gene A)-related 6''; IBO1; NIMA (never in mitosis; NIMA-RELATED KINASE6
    Summary
    Encodes AtNek5, a member of the NIMA-related serine/threonine kinases (Neks) that have been linked to cell-cycle regulation in fungi and mammals. Plant Neks might be involved in plant development processes.Interacts physically with plant kinesins ARK1 and ARK2. Mutants show defects in root epidermal cell morphology, trichome branching and other epidermal cell abnormalities suggesting a rol e in epidermal cell differentiation. NEK6 co-localizes with cortical microtubules.
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    Genomic context

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    See NEK6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (15906348..15912040)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene syntaxin-related family protein Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubule Response to Tensile Stress Is Curbed by NEK6 to Buffer Growth Variation in the Arabidopsis Hypocotyl. Takatani S, et al. Curr Biol, 2020 Apr 20. PMID 32169210
    2. Directional cell expansion requires NIMA-related kinase 6 (NEK6)-mediated cortical microtubule destabilization. Takatani S, et al. Sci Rep, 2017 Aug 10. PMID 28798328, Free PMC Article
    3. NIMA-related kinases regulate directional cell growth and organ development through microtubule function in Arabidopsis thaliana. Motose H, et al. Plant Signal Behav, 2012 Dec. PMID 23072999, Free PMC Article
    4. A NIMA-related protein kinase suppresses ectopic outgrowth of epidermal cells through its kinase activity and the association with microtubules. Motose H, et al. Plant J, 2008 Jun. PMID 18266916
    5. The ARM Domain of ARMADILLO-REPEAT KINESIN 1 is Not Required for Microtubule Catastrophe But Can Negatively Regulate NIMA-RELATED KINASE 6 in Arabidopsis thaliana. Eng RC, et al. Plant Cell Physiol, 2017 Aug 1. PMID 28505371

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Microtubule Response to Tensile Stress Is Curbed by NEK6 to Buffer Growth Variation in the Arabidopsis Hypocotyl.
      Title: Microtubule Response to Tensile Stress Is Curbed by NEK6 to Buffer Growth Variation in the Arabidopsis Hypocotyl.
    2. Results suggest that NEK6 promotes directional cell growth through phosphorylation of beta-tubulin and the resulting destabilization of cortical microtubules.
      Title: Directional cell expansion requires NIMA-related kinase 6 (NEK6)-mediated cortical microtubule destabilization.
    3. ARK1 and NEK6 function independently in microtubule dynamics and cell morphogenesis.
      Title: The ARM Domain of ARMADILLO-REPEAT KINESIN 1 is Not Required for Microtubule Catastrophe But Can Negatively Regulate NIMA-RELATED KINASE 6 in Arabidopsis thaliana.
    4. Data demonstrated that NEK6 is required for the directional growth of roots and hypocotyls, petiole elongation, cell file formation, and trichome morphogenesis.
      Title: NIMA-related kinases regulate directional cell growth and organ development through microtubule function in Arabidopsis thaliana.
    5. NEK6 regulates rosette growth and yield-related traits in Arabidopsis.
      Title: NIMA-related kinase NEK6 affects plant growth and stress response in Arabidopsis.
    6. NEK6 homodimerizes and forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
      Title: NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana.
    7. interacts with ARIA and is involved in abscisic acid response during seed germination
      Title: AtNEK6 interacts with ARIA and is involved in ABA response during seed germination.
    8. ibo1-1 mutation, in which a conserved Glu residue in the activation loop is substituted by Arg, completely abolishes its kinase activity
      Title: A NIMA-related protein kinase suppresses ectopic outgrowth of epidermal cells through its kinase activity and the association with microtubules.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339123.1
    NM_114288.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase NEK5
    NP_190006.2
    • ''NIMA (never in mitosis, gene A)-related 6'' (NEK6); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: microtubule-based process, epidermal cell differentiation; LOCATED IN: cortical microtubule; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related serine/threonine kinase 1 (TAIR:AT1G54510.3); Has 127749 Blast hits to 124714 proteins in 4408 species: Archae - 106; Bacteria - 14910; Metazoa - 47444; Fungi - 12949; Plants - 30417; Viruses - 519; Other Eukaryotes - 21404 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      15906348..15912040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114288.4 → NP_190006.2  serine/threonine-protein kinase NEK5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190006.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9CP44, Q0WPH8, Q9LXP3
      UniProtKB/TrEMBL
      A0A178V654, A0A5S9XHS5, A0A654FCR6
      Conserved Domains (1) summary
      cd08215
      Location:7 → 262
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

    2. NM_001339123.1 → NP_001327688.1  serine/threonine-protein kinase NEK5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9CP44, Q0WPH8, Q9LXP3
      UniProtKB/TrEMBL
      A0A178V654, A0A5S9XHS5, A0A654FCR6
      Conserved Domains (1) summary
      cd08215
      Location:7 → 262
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WPH8.1

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