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    COPT2 copper transporter 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823843, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COPT2
    Official Full Name
    copper transporter 2
    Primary source
    TAIR:AT3G46900
    Locus tag
    AT3G46900
    See related
    Araport:AT3G46900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    copper transporter 2
    Summary
    encodes a member of copper transporter family and functionally complements a high affinity copper transporter mutant in yeast
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    Genomic context

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    See COPT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (17268700..17269510)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene maternal effect embryo arrest protein Neighboring gene miscRNA Neighboring gene Cullin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-independent proteasome system is required for degradation of Arabidopsis COPPER TRANSPORTER 2. Li J, et al. Plant Sci, 2021 Mar. PMID 33568283
    2. Arabidopsis copper transport protein COPT2 participates in the cross talk between iron deficiency responses and low-phosphate signaling. Perea-García A, et al. Plant Physiol, 2013 May. PMID 23487432, Free PMC Article
    3. Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana. Perea-García A, et al. J Exp Bot, 2016 Jan. PMID 26516126, Free PMC Article
    4. Identification of a copper transporter family in Arabidopsis thaliana. Sancenón V, et al. Plant Mol Biol, 2003 Mar. PMID 12650623
    5. The CTR/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in A. thaliana. Gayomba SR, et al. Metallomics, 2013 Sep. PMID 23835944

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin-independent proteasome system is required for degradation of Arabidopsis COPPER TRANSPORTER 2.
      Title: Ubiquitin-independent proteasome system is required for degradation of Arabidopsis COPPER TRANSPORTER 2.
    2. The expression of SPL7 and its targets COPT2 and FSD1 was differently regulated in various light signalling mutants. Under copper deficiency, the expression of both targets decreased drastically in continuous darkness.
      Title: Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana.
    3. Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2, COPT6, CSD1, CSD2, miRNA398 b/c precursors and FSD1.
      Title: The CTR/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in A. thaliana.
    4. The phenotypes and gene expression changes displayed by a copt2-1 line reveal a role for COPT2 in the cross talk among Cu, Fe, and Pi deficiency responses in Arabidopsis.
      Title: Arabidopsis copper transport protein COPT2 participates in the cross talk between iron deficiency responses and low-phosphate signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_114557.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables high-affinity copper ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within copper ion import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    copper transporter 2
    NP_190274.1
    • copper transporter 2 (COPT2); FUNCTIONS IN: copper ion transmembrane transporter activity, high affinity copper ion transmembrane transporter activity; INVOLVED IN: copper ion transport, high-affinity copper ion transport; LOCATED IN: anchored to plasma membrane; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Ctr copper transporter (InterPro:IPR007274); BEST Arabidopsis thaliana protein match is: Ctr copper transporter family (TAIR:AT2G26975.1); Has 445 Blast hits to 445 proteins in 119 species: Archae - 0; Bacteria - 0; Metazoa - 186; Fungi - 45; Plants - 164; Viruses - 0; Other Eukaryotes - 50 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17268700..17269510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114557.3 → NP_190274.1  copper transporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9STG2
      UniProtKB/TrEMBL
      A0A178VCX7, A0A5S9XJ94, A0A7G2ES15
      Conserved Domains (1) summary
      pfam04145
      Location:34 → 132
      Ctr; Ctr copper transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STG2.1

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