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    PYE basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823918, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PYE
    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT3G47640
    Locus tag
    AT3G47640
    See related
    Araport:AT3G47640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    POPEYE
    Summary
    Encodes POPEYE (PYE), a bHLH transcription factor regulating response to iron deficiency in Arabidopsis roots.
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    Genomic context

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    See PYE in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (17567126..17569394)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene TEOSINTE BRANCHED, cycloidea and PCF (TCP) 14 Neighboring gene translocator assembly/maintenance protein Neighboring gene DnaJ/Hsp40 cysteine-rich domain superfamily protein Neighboring gene Regulator of chromosome condensation (RCC1) family protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transcription factor POPEYE negatively regulates the expression of bHLH Ib genes to maintain iron homeostasis. Pu MN, et al. J Exp Bot, 2023 Apr 18. PMID 36787175, Free PMC Article
    2. Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3. Akmakjian GZ, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34580211, Free PMC Article
    3. Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors. Selote D, et al. Plant Physiol, 2015 Jan. PMID 25452667, Free PMC Article
    4. The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. Long TA, et al. Plant Cell, 2010 Jul. PMID 20675571, Free PMC Article
    5. The development of protein microarrays and their applications in DNA-protein and protein-protein interaction analyses of Arabidopsis transcription factors. Gong W, et al. Mol Plant, 2008 Jan. PMID 19802365, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transcription factor POPEYE negatively regulates the expression of bHLH Ib genes to maintain iron homeostasis.
      Title: The transcription factor POPEYE negatively regulates the expression of bHLH Ib genes to maintain iron homeostasis.
    2. Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3.
      Title: Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203101.1
    NM_114632.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to iron ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_001190029.1
    • POPEYE (PYE); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: cellular response to iron ion starvation, iron ion homeostasis, regulation of transcription; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G36060.1).
    NP_001190030.1
    • POPEYE (PYE); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: cellular response to iron ion starvation, iron ion homeostasis, regulation of transcription; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G36060.1).
    NP_190348.1
    • POPEYE (PYE); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: cellular response to iron ion starvation, iron ion homeostasis, regulation of transcription; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G36060.1); Has 345 Blast hits to 345 proteins in 44 species: Archae - 0; Bacteria - 0; Metazoa - 15; Fungi - 0; Plants - 321; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17567126..17569394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203100.1 → NP_001190029.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190029.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SN74
      UniProtKB/TrEMBL
      A0A178VI35, A0A5S9XIQ6, A0A654FHH8
      Conserved Domains (1) summary
      cd11446
      Location:32 → 106
      bHLH_AtILR3_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins

    2. NM_001203101.1 → NP_001190030.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SN74
      UniProtKB/TrEMBL
      A0A178VI35, A0A5S9XIQ6, A0A654FHH8
      Conserved Domains (1) summary
      cd11446
      Location:32 → 106
      bHLH_AtILR3_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins

    3. NM_114632.4 → NP_190348.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SN74
      UniProtKB/TrEMBL
      A0A178VI35, A0A5S9XIQ6, A0A654FHH8
      Conserved Domains (1) summary
      cd11446
      Location:32 → 106
      bHLH_AtILR3_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SN74.1

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