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    MTPA2 metal tolerance protein A2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825050, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MTPA2
    Official Full Name
    metal tolerance protein A2
    Primary source
    TAIR:AT3G58810
    Locus tag
    AT3G58810
    See related
    Araport:AT3G58810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS METAL TOLERANCE PROTEIN 3; ATMTP3; ATMTPA2; METAL TOLERANCE PROTEIN 3; metal tolerance protein A2; MTP3
    Summary
    Member of Zinc transporter (ZAT) family. Contributes to basic cellular Zn tolerance and controls Zn partitioning, particularly under conditions of high rates of Zn influx into the root symplasm. Localizes to the vacuolar membrane.
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    Genomic context

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    See MTPA2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (21749966..21752141)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene galacturonosyltransferase 15 Neighboring gene ncRNA Neighboring gene secretion-regulating guanine nucleotide exchange factor Neighboring gene F-box/RNI-like superfamily protein Neighboring gene haloacid dehalogenase (HAD) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systemic Upregulation of MTP2- and HMA2-Mediated Zn Partitioning to the Shoot Supplements Local Zn Deficiency Responses. Sinclair SA, et al. Plant Cell, 2018 Oct. PMID 30150315, Free PMC Article
    2. The Arabidopsis metal tolerance protein AtMTP3 maintains metal homeostasis by mediating Zn exclusion from the shoot under Fe deficiency and Zn oversupply. Arrivault S, et al. Plant J, 2006 Jun. PMID 16709200
    3. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
    4. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Root MTP2 transcript levels depends on shoot Zn status.HMA2 and MTP2 act together in Zn deficiency.
      Title: Systemic Upregulation of MTP2- and HMA2-Mediated Zn Partitioning to the Shoot Supplements Local Zn Deficiency Responses.
    2. The MTP3 protein contributes to basic cellular Zinc tolerance and controls Zinc partitioning, particularly under conditions of high rates of Zinc influx into the root symplasm. [MTP3]
      Title: The Arabidopsis metal tolerance protein AtMTP3 maintains metal homeostasis by mediating Zn exclusion from the shoot under Fe deficiency and Zn oversupply.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115743.3
    NM_202727.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inorganic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within detoxification of cobalt ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within detoxification of zinc ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    metal tolerance protein A2
    NP_191440.2
    • metal tolerance protein A2 (MTPA2); FUNCTIONS IN: efflux transmembrane transporter activity, zinc ion transmembrane transporter activity, inorganic anion transmembrane transporter activity; INVOLVED IN: response to zinc ion, zinc ion transport, detoxification of cobalt ion, detoxification of zinc ion; LOCATED IN: plant-type vacuole membrane, vacuole; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cation efflux protein (InterPro:IPR002524); BEST Arabidopsis thaliana protein match is: zinc transporter of Arabidopsis thaliana (TAIR:AT2G46800.2); Has 9971 Blast hits to 8160 proteins in 2151 species: Archae - 138; Bacteria - 5614; Metazoa - 2175; Fungi - 680; Plants - 377; Viruses - 8; Other Eukaryotes - 979 (source: NCBI BLink).
    NP_974456.1
    • metal tolerance protein A2 (MTPA2); CONTAINS InterPro DOMAIN/s: Cation efflux protein (InterPro:IPR002524); BEST Arabidopsis thaliana protein match is: zinc transporter of Arabidopsis thaliana (TAIR:AT2G46800.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21749966..21752141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202727.3 → NP_974456.1  metal tolerance protein A2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1H8W9, Q9LXS1
      UniProtKB/TrEMBL
      Q0WT11
      Conserved Domains (2) summary
      TIGR01297
      Location:83 → 391
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:83 → 314
      Cation_efflux; Cation efflux family

    2. NM_115743.3 → NP_191440.2  metal tolerance protein A2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191440.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XM48, Q3EAH9
      Conserved Domains (2) summary
      TIGR01297
      Location:122 → 430
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:122 → 353
      Cation_efflux; Cation efflux family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LXS1.2

    Gene LinkOut

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