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    NMT1 myristoyl-CoA:protein N-myristoyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NMT1
    Official Full Name
    myristoyl-CoA:protein N-myristoyltransferase
    Primary source
    TAIR:AT5G57020
    Locus tag
    AT5G57020
    See related
    Araport:AT5G57020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE; ATNMT1; MHM17.15; MHM17_15; myristoyl-CoA:protein N-myristoyltransferase; N-MYRISTOYLTRANSFERASE 1
    Summary
    Arabidopsis thaliana myristoyl-CoA:protein N-myristoyltransferase.
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    Genomic context

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    See NMT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (23074867..23077193)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene calmodulin-binding family protein Neighboring gene casein kinase I-like 12 Neighboring gene Lycopene beta/epsilon cyclase protein Neighboring gene U-box domain-containing protein kinase family protein Neighboring gene Lactoylglutathione lyase / glyoxalase I family protein Neighboring gene Protein phosphatase 2C family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Golgi traffic and integrity depend on N-myristoyl transferase-1 in Arabidopsis. Renna L, et al. Plant Cell, 2013 May. PMID 23673980, Free PMC Article
    2. N-myristoylation regulates the SnRK1 pathway in Arabidopsis. Pierre M, et al. Plant Cell, 2007 Sep. PMID 17827350, Free PMC Article
    3. NMT1 and NMT3 N-Methyltransferase Activity Is Critical to Lipid Homeostasis, Morphogenesis, and Reproduction. Chen W, et al. Plant Physiol, 2018 Aug. PMID 29777000, Free PMC Article
    4. Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana. Qi Q, et al. J Biol Chem, 2000 Mar 31. PMID 10734119
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMT1 role in reproduction and seed development.
      Title: NMT1 and NMT3 N-Methyltransferase Activity Is Critical to Lipid Homeostasis, Morphogenesis, and Reproduction.
    2. Results indicate the postembryonic functions of N-myristoyltransferases NMT1 involve regulation of the functional and morphological integrity of the plant endomembranes.
      Title: Golgi traffic and integrity depend on N-myristoyl transferase-1 in Arabidopsis.
    3. Protein N-myristoylation is systematically associated with shoot meristem development and that SnRK1 (for SNF1-related kinase) is one of its essential primary targets. [NMT1]
      Title: N-myristoylation regulates the SnRK1 pathway in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125084.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glycylpeptide N-tetradecanoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myristoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myristoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-terminal protein myristoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic shoot morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myristoyl-CoA:protein N-myristoyltransferase
    NP_568846.1
    • myristoyl-CoA:protein N-myristoyltransferase (NMT1); CONTAINS InterPro DOMAIN/s: Myristoyl-CoA:protein N-myristoyltransferase (InterPro:IPR000903), Myristoyl-CoA:protein N-myristoyltransferase, conserved site (InterPro:IPR022678), Myristoyl-CoA:protein N-myristoyltransferase, N-terminal (InterPro:IPR022676), Acyl-CoA N-acyltransferase (InterPro:IPR016181), Myristoyl-CoA:protein N-myristoyltransferase, C-terminal (InterPro:IPR022677); BEST Arabidopsis thaliana protein match is: Acyl-CoA N-acyltransferases (NAT) superfamily protein (TAIR:AT2G44175.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23074867..23077193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125084.3 → NP_568846.1  myristoyl-CoA:protein N-myristoyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568846.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTR9, Q9M6E3
      UniProtKB/TrEMBL
      A0A178UUQ9, A0A5S9YEP7
      Conserved Domains (1) summary
      COG5092
      Location:24 → 421
      NMT1; N-myristoyl transferase [Lipid metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTR9.2

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