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    PTPRG protein tyrosine phosphatase receptor type G [ Homo sapiens (human) ]

    Gene ID: 5793, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PTPRGprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Gprovided by HGNC
    Primary source
    HGNC:HGNC:9671
    See related
    Ensembl:ENSG00000144724 MIM:176886; AllianceGenome:HGNC:9671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTPG; HPTPG; RPTPG; R-PTP-GAMMA
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 11.5), kidney (RPKM 9.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTPRG in Genome Data Viewer
    Location:
    3p14.2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (61561571..62297609)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (61604735..62341118)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (61547245..62283284)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909387 Neighboring gene uncharacterized LOC105377114 Neighboring gene Sharpr-MPRA regulatory region 1523 Neighboring gene uncharacterized LOC105377115 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61317711-61318325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14495 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:61404092-61404295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:61490728-61491228 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:61491229-61491729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61545347-61546022 Neighboring gene uncharacterized LOC124909388 Neighboring gene uncharacterized LOC124906245 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:61657567-61658404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61665901-61666400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61671542-61672277 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61673811-61674444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61676017-61676556 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61677824-61678324 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61678325-61678825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61678925-61679473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61680893-61681393 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61685048-61685943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61686839-61687733 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61689953-61690680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61690681-61691408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61700687-61701188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61701189-61701688 Neighboring gene ribosomal protein L10a pseudogene 6 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:61815091-61815694 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:61815695-61816299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61852378-61852880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61852881-61853381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61857459-61858243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61860549-61861255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:61932324-61933045 Neighboring gene Sharpr-MPRA regulatory region 14465 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:62026884-62028083 Neighboring gene NANOG hESC enhancer GRCh37_chr3:62155504-62156044 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_70816 Neighboring gene RNA, U2 small nuclear 10, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62175493-62176339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:62176867-62177367 Neighboring gene uncharacterized LOC124909389 Neighboring gene inhibitor of DNA binding 2B (pseudogene) Neighboring gene PTPRG antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9750 Neighboring gene VISTA enhancer hs434 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62353809-62354715 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62354716-62355621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62357949-62358508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62358509-62359066 Neighboring gene centrosomal protein 15 Neighboring gene FEZ family zinc finger 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Methylation of PTPRG gene and its regulation in gastric cancer]. Wang JF, et al. Zhonghua Zhong Liu Za Zhi, 2008 Feb. PMID 18646686
    2. Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar. Ismail MA, et al. Mol Genet Genomic Med, 2020 Oct. PMID 32700424, Free PMC Article
    3. A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients. Vezzalini M, et al. J Hematol Oncol, 2017 Jun 21. PMID 28637510, Free PMC Article
    4. Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series. Galvan A, et al. Int J Cancer, 2015 Mar 1. PMID 25196286
    5. Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms. Kish K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jul 1. PMID 21795790, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma.
      Title: Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma.
    2. The EGFR phosphatase RPTPgamma is a redox-regulated suppressor of promigratory signaling.
      Title: The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling.
    3. Loss of RPTPgamma primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.
      Title: Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.
    4. Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG.
      Title: Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG.
    5. A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease.
      Title: A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease.
    6. Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors.
      Title: Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors.
    7. Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients.
      Title: Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients.
    8. Activation of Protein Tyrosine Phosphatase Receptor Type gamma Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells.
      Title: Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells.
    9. Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.
      Title: Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.
    10. PTPRG is an ischemia risk locus essential for HCO3(-)-dependent regulation of endothelial function and tissue perfusion.
      Title: PTPRG is an ischemia risk locus essential for HCO(3)(-)-dependent regulation of endothelial function and tissue perfusion.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
    EBI GWAS Catalog
    E2-2 protein and Fuchs's corneal dystrophy.
    EBI GWAS Catalog
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog
    Genome-wide association study identifies five new schizophrenia loci.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog
    Genome-wide association study of recurrent early-onset major depressive disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in regulation of homophilic cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase gamma
    Names
    H_RG317H01.1
    protein tyrosine phosphatase gamma
    protein tyrosine phosphatase, receptor type, gamma polypeptide
    receptor type protein tyrosine phosphatase gamma
    receptor tyrosine phosphatase gamma
    receptor-type protein phosphatase gamma
    NP_001362400.1
    NP_002832.3
    XP_016862450.1
    XP_016862451.1
    XP_016862452.1
    XP_047304601.1
    XP_047304602.1
    XP_054203384.1
    XP_054203385.1
    XP_054203386.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375471.1 → NP_001362400.1  receptor-type tyrosine-protein phosphatase gamma isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004695, AC092502, AC096919, AC098482, AC103587, AC104849
      Consensus CDS
      CCDS93303.1
      Related
      ENSP00000295874.10, ENST00000295874.14
      Conserved Domains (5) summary
      PHA03169
      Location:544 → 702
      PHA03169; hypothetical protein; Provisional
      cd00063
      Location:348 → 438
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd03122
      Location:67 → 319
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      cd17667
      Location:819 → 1092
      R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1
      cd17670
      Location:1176 → 1380
      R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2

    2. NM_002841.4 → NP_002832.3  receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor

      See identical proteins and their annotated locations for NP_002832.3

      Status: REVIEWED

      Source sequence(s)
      AC092502, BC036018, BC140904
      Consensus CDS
      CCDS2895.1
      UniProtKB/Swiss-Prot
      B2RU12, B7ZLX5, P23470, Q15623, Q59EE0, Q68DU5
      Related
      ENSP00000418112.1, ENST00000474889.6
      Conserved Domains (5) summary
      PHA03169
      Location:544 → 702
      PHA03169; hypothetical protein; Provisional
      cd00063
      Location:348 → 438
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd03122
      Location:67 → 319
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      cd17667
      Location:848 → 1121
      R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1
      cd17670
      Location:1205 → 1409
      R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      61561571..62297609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006961.2 → XP_016862450.1  receptor-type tyrosine-protein phosphatase gamma isoform X1

    2. XM_017006963.2 → XP_016862452.1  receptor-type tyrosine-protein phosphatase gamma isoform X3

    3. XM_047448646.1 → XP_047304602.1  receptor-type tyrosine-protein phosphatase gamma isoform X4

    4. XM_047448645.1 → XP_047304601.1  receptor-type tyrosine-protein phosphatase gamma isoform X4

    5. XM_017006962.1 → XP_016862451.1  receptor-type tyrosine-protein phosphatase gamma isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      61604735..62341118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347409.1 → XP_054203384.1  receptor-type tyrosine-protein phosphatase gamma isoform X1

    2. XM_054347411.1 → XP_054203386.1  receptor-type tyrosine-protein phosphatase gamma isoform X3

    3. XM_054347410.1 → XP_054203385.1  receptor-type tyrosine-protein phosphatase gamma isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23470.4 GenPept UniProtKB/Swiss-Prot:P23470

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