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    TARS3 threonyl-tRNA synthetase 3 [ Homo sapiens (human) ]

    Gene ID: 123283, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TARS3provided by HGNC
    Official Full Name
    threonyl-tRNA synthetase 3provided by HGNC
    Primary source
    HGNC:HGNC:24728
    See related
    Ensembl:ENSG00000185418 AllianceGenome:HGNC:24728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TARSL2; ThrRS-L
    Summary
    Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See TARS3 in Genome Data Viewer
    Location:
    15q26.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101653596..101724473, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99411600..99482344, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (102193799..102264676, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102152533-102153033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102153852-102154370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102154371-102154887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102157328-102157940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6891 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:102186842-102187008 Neighboring gene TM2 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:102192988-102193878 Neighboring gene RNA, U6 small nuclear 807, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102215750-102216274 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:102216275-102216797 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6894 Neighboring gene UBE2Q2 pseudogene 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:102286622-102286992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:102303375-102304574 Neighboring gene dynamin 1 pseudogene 47

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex. Zhou XL, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287872, Free PMC Article
    2. miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression. Liu Y, et al. Hum Cell, 2021 Sep. PMID 34024034
    3. A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities. Chen Y, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29579307, Free PMC Article
    4. Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. Kim K, et al. PLoS One, 2013. PMID 24312579, Free PMC Article
    5. VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability. Yu X, et al. Biochem Biophys Res Commun, 2015 Apr 3. PMID 25732088, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression.
      Title: miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression.
    2. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
      Title: Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
    3. TARSL2 is potentially a new component of aminoacyl-tRNA synthetase core-complex
      Title: Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25005

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    threonine--tRNA ligase 2, cytoplasmic
    Names
    probable threonine--tRNA ligase 2, cytoplasmic
    probable threonyl-tRNA synthetase 2, cytoplasmic
    thrRS
    threonyl-tRNA synthetase like 2
    threonyl-tRNA synthetase protein 3
    threonyl-tRNA synthetase-like protein 2
    NP_689547.2
    XP_016877401.1
    XP_047288096.1
    XP_047288098.1
    XP_054233241.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152334.3 → NP_689547.2  threonine--tRNA ligase 2, cytoplasmic

      See identical proteins and their annotated locations for NP_689547.2

      Status: VALIDATED

      Source sequence(s)
      AC027559, AC090164, AK056653, AL833188, AW161214, BE856588, BU677165
      Consensus CDS
      CCDS10394.1
      UniProtKB/Swiss-Prot
      A2RTX5, B2RMP7, Q6B0A1, Q6IS76, Q96LW3, Q96MP4
      UniProtKB/TrEMBL
      B7ZLP8
      Related
      ENSP00000338093.3, ENST00000335968.8
      Conserved Domains (5) summary
      cd01667
      Location:162 → 223
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:122 → 795
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:329 → 376
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:400 → 697
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:697 → 788
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      101653596..101724473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432142.1 → XP_047288098.1  threonine--tRNA ligase 2, cytoplasmic isoform X3

    2. XM_047432140.1 → XP_047288096.1  threonine--tRNA ligase 2, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      B7ZLP8
      Related
      ENSP00000478827.1, ENST00000615656.1

    3. XM_017021912.3 → XP_016877401.1  threonine--tRNA ligase 2, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      B7ZLP8
      Conserved Domains (1) summary
      PLN02908
      Location:122 → 655
      PLN02908; threonyl-tRNA synthetase

    RNA

    1. XR_007064422.1 RNA Sequence

    2. XR_931749.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      99411600..99482344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377266.1 → XP_054233241.1  threonine--tRNA ligase 2, cytoplasmic isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RTX5.1 GenPept UniProtKB/Swiss-Prot:A2RTX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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