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    IL13RA1 interleukin 13 receptor subunit alpha 1 [ Homo sapiens (human) ]

    Gene ID: 3597, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IL13RA1provided by HGNC
    Official Full Name
    interleukin 13 receptor subunit alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:5974
    See related
    Ensembl:ENSG00000131724 MIM:300119; AllianceGenome:HGNC:5974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NR4; CT19; CD213A1; IL-13Ra
    Summary
    The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See IL13RA1 in Genome Data Viewer
    Location:
    Xq24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (118727606..118805228)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (117105336..117182975)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (117861569..117928496)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 11 Neighboring gene RBBP8 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:117831262-117831491 Neighboring gene uncharacterized LOC124905207 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20950 Neighboring gene small nucleolar RNA SNORA35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:117904251-117904750 Neighboring gene TMEM30B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20951 Neighboring gene zinc finger CCHC-type containing 12 Neighboring gene long intergenic non-protein coding RNA 1285 Neighboring gene AKR7A2P pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer. Shi J, et al. Int J Mol Sci, 2022 Mar 26. PMID 35409019, Free PMC Article
    2. Mutation and functional analysis of IL-13 receptors in human malignant glioma cells. Kawakami M, et al. Oncol Res, 2001. PMID 11939409
    3. The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4. Sheikh F, et al. J Innate Immun, 2015. PMID 25766112, Free PMC Article
    4. Identification of single-nucleotide and repeat polymorphisms in two candidate genes, interleukin 4 receptor (IL4RA) and signal transducer and activator of transcription protein 6 (STAT6), for Th2-mediated diseases. Nagarkatti R, et al. J Hum Genet, 2002. PMID 12522691
    5. Kinetic analysis of the interleukin-13 receptor complex. Andrews AL, et al. J Biol Chem, 2002 Nov 29. PMID 12354755

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation.
      Title: MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation.
    2. Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.
      Title: Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.
    3. Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
      Title: Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
    4. IL-13 and IL-13Ralpha1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.
      Title: IL-13 and IL-13Rα1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.
    5. High IL13RA1 expression is associated with Invasive breast Cancer.
      Title: Elevated Interleukin-13 Receptor Alpha 1 Expression in Tumor Cells Is Associated with Poor Prognosis in Patients with Invasive Breast Cancer.
    6. in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease.
      Title: New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.
    7. IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
      Title: IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells.
    8. sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism.
      Title: Soluble interleukin-13rα1: a circulating regulator of glucose.
    9. these data suggest that microRNA-143 suppresses IL-13 activity and inflammation through targeting of IL-13Ralpha1 in epidermal keratinocytes
      Title: MicroRNA-143 inhibits IL-13-induced dysregulation of the epidermal barrier-related proteins in skin keratinocytes via targeting to IL-13Rα1.
    10. IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair.
      Title: A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of interleukin 13 receptor, alpha 1 gene (IL13RA1) in mammary epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of immunoglobulin production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of interleukin-13 receptor complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-13 receptor subunit alpha-1
    Names
    CD213a1 antigen
    IL-13 receptor subunit alpha-1
    IL-13R subunit alpha-1
    IL13 receptor alpha-1 chain
    cancer/testis antigen 19
    interleukin 13 receptor, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012841.1 RefSeqGene

      Range
      5011..71938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001560.3 → NP_001551.1  interleukin-13 receptor subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_001551.1

      Status: REVIEWED

      Source sequence(s)
      AL391280
      Consensus CDS
      CCDS14573.1
      UniProtKB/Swiss-Prot
      O95646, P78552, Q5JSL4, Q99656, Q9UDY5
      UniProtKB/TrEMBL
      Q8WX08, Q96BB4
      Related
      ENSP00000360730.3, ENST00000371666.8
      Conserved Domains (2) summary
      cd00063
      Location:228 → 336
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:131 → 224
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      118727606..118805228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442096.1 → XP_047298052.1  interleukin-13 receptor subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      Q8WX08, Q96BB4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      117105336..117182975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327031.1 → XP_054183006.1  interleukin-13 receptor subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      Q8WX08, Q96BB4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78552.1 GenPept UniProtKB/Swiss-Prot:P78552

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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