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    PYY peptide YY [ Homo sapiens (human) ]

    Gene ID: 5697, updated on 10-Dec-2024

    Summary

    Official Symbol
    PYYprovided by HGNC
    Official Full Name
    peptide YYprovided by HGNC
    Primary source
    HGNC:HGNC:9748
    See related
    Ensembl:ENSG00000131096 MIM:600781; AllianceGenome:HGNC:9748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PYY1; PYY-I
    Summary
    This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in colon (RPKM 24.9) and small intestine (RPKM 4.4) See more
    Orthologs
    NEW
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    Genomic context

    See PYY in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43952733..44004445, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44805282..44856956, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42030101..42081813, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42015415-42015915 Neighboring gene long intergenic non-protein coding RNA 1976 Neighboring gene pancreatic polypeptide Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42030343-42030846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42082913-42083668 Neighboring gene Sharpr-MPRA regulatory region 11566 Neighboring gene N-acetylglutamate synthase Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:42091474-42092673 Neighboring gene Sharpr-MPRA regulatory region 15580 Neighboring gene transmembrane protein 101

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (7 hits/1250 screens)

    EBI GWAS Catalog

    Description
    Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding PubMed 
    enables hormone activity PubMed 
    enables neuropeptide Y receptor binding  
    enables neuropeptide hormone activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in feeding behavior  
    involved_in intestinal epithelial cell differentiation PubMed 
    involved_in neuropeptide signaling pathway  
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  

    General protein information

    Preferred Names
    peptide YY
    Names
    peptide tyrosine tyrosine
    prepro-PYY

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023338.2 RefSeqGene

      Range
      55505..56712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394028.1 → NP_001380957.1  peptide YY isoform 1 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC007993
      Consensus CDS
      CCDS32662.1
      UniProtKB/Swiss-Prot
      P10082, Q5U5Q6, Q6FGH8
      Related
      ENSP00000509262.1, ENST00000692052.1
      Conserved Domains (1) summary
      smart00309
      Location:29 → 64
      PAH; Pancreatic hormones / neuropeptide F / peptide YY family
    2. NM_001394029.1 → NP_001380958.1  peptide YY isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007993
      Consensus CDS
      CCDS92333.1
      Related
      ENSP00000467310.1, ENST00000592796.2
      Conserved Domains (1) summary
      smart00309
      Location:29 → 64
      PAH; Pancreatic hormones / neuropeptide F / peptide YY family
    3. NM_004160.6 → NP_004151.4  peptide YY isoform 1 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC007993, AC023855
      Consensus CDS
      CCDS32662.1
      UniProtKB/Swiss-Prot
      P10082, Q5U5Q6, Q6FGH8
      Related
      ENSP00000353198.1, ENST00000360085.6
      Conserved Domains (1) summary
      smart00309
      Location:29 → 64
      PAH; Pancreatic hormones / neuropeptide F / peptide YY family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43952733..44004445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44805282..44856956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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