U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 [ Homo sapiens (human) ]

    Gene ID: 5504, updated on 27-Dec-2024

    Summary

    Official Symbol
    PPP1R2provided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory inhibitor subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:9288
    See related
    Ensembl:ENSG00000184203 MIM:601792; AllianceGenome:HGNC:9288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IPP2; IPP-2; PPP1R2A
    Summary
    Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPP1R2 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195514428..195543325, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (198221391..198250329, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195241224..195270148, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Neighboring gene ribosomal protein L31 pseudogene 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21054 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195154512-195155012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195163293-195163792 Neighboring gene uncharacterized LOC124906341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:195190192-195191391 Neighboring gene MPRA-validated peak4984 silencer Neighboring gene RNA, U6atac small nuclear 24, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15040 Neighboring gene RNA, 7SL, cytoplasmic 73, pseudogene Neighboring gene RPL24 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC87148

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    protein phosphatase inhibitor 2
    Names
    phosphoprotein phosphatase
    NP_001278433.1
    NP_001278434.1
    NP_001303254.1
    NP_006232.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291504.2 → NP_001278433.1  protein phosphatase inhibitor 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC069213
      UniProtKB/TrEMBL
      E7EMN6
      Conserved Domains (1) summary
      pfam04979
      Location:45 → 164
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    2. NM_001291505.2 → NP_001278434.1  protein phosphatase inhibitor 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC069213
      UniProtKB/TrEMBL
      E7EMN6
      Related
      ENSP00000400238.1, ENST00000438848.5
      Conserved Domains (1) summary
      pfam04979
      Location:45 → 137
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    3. NM_001316325.2 → NP_001303254.1  protein phosphatase inhibitor 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC069213, BC007655, BI560631
      UniProtKB/Swiss-Prot
      P41236
      Conserved Domains (1) summary
      pfam04979
      Location:52 → 143
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    4. NM_006241.8 → NP_006232.1  protein phosphatase inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_006232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA259068, AC069213, BC007655
      Consensus CDS
      CCDS3309.1
      UniProtKB/Swiss-Prot
      P41236
      UniProtKB/TrEMBL
      E7EMN6
      Related
      ENSP00000484580.1, ENST00000618156.5
      Conserved Domains (1) summary
      pfam04979
      Location:45 → 164
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

    RNA

    1. NR_133014.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC069213, BC007655, BI549862

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      195514428..195543325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      198221391..198250329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.