Fastkd2 FAST kinase domains 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fastkd2provided by RGD
Official Full Name: FAST kinase domains 2provided by RGD
Primary source: RGD:1307883
See related: EnsemblRapid:ENSRNOG00000023923 AllianceGenome:RGD:1307883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307883
Summary: Predicted to enable rRNA binding activity. Predicted to be involved in several processes, including mitochondrial gene expression; mitochondrial large ribosomal subunit assembly; and post-transcriptional regulation of gene expression. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 44. Orthologous to human FASTKD2 (FAST kinase domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 85.8), Muscle (RPKM 68.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (72659961..72681986)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (65166148..65188184)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (70448386..70471420)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables rRNA binding	ISO Inferred from Sequence Orthology more info
enables rRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in RNA processing	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial large ribosomal subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial large ribosomal subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial large ribosomal subunit assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial translation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial mRNA stability	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
located_in ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in ribonucleoprotein granule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: FAST kinase domain-containing protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009673.1 → NP_001009673.1 FAST kinase domain-containing protein 2, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_001009673.1

Status: PROVISIONAL

Source sequence(s)

BC088416

UniProtKB/Swiss-Prot

Q5M7V7

Conserved Domains (4) summary

smart00952
Location:609 → 665

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:433 → 502

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:551 → 586

FAST_2; FAST kinase-like protein, subdomain 2

pfam08689
Location:356 → 516

Med5; Mediator complex subunit Med5
NM_001398523.1 → NP_001385452.1 FAST kinase domain-containing protein 2, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A0H2UHK3, A6IPH0

Related

ENSRNOP00000112158.1, ENSRNOT00000159270.1

Conserved Domains (3) summary

smart00952
Location:619 → 675

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:443 → 512

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:561 → 596

FAST_2; FAST kinase-like protein, subdomain 2