Atg2a autophagy related 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atg2aprovided by RGD
Official Full Name: autophagy related 2Aprovided by RGD
Primary source: RGD:1589890
See related: EnsemblRapid:ENSRNOG00000060707 AllianceGenome:RGD:1589890
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lipid transfer activity; phosphatidylinositol-3-phosphate binding activity; and protein-membrane adaptor activity. Predicted to be involved in autophagy of mitochondrion; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in organelle membrane contact site; phagophore; and phagophore assembly site. Orthologous to human ATG2A (autophagy related 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 51.1), Adrenal (RPKM 46.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (212971822..212991505)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203542559..203562242)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221612584..221632291)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in pexophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
is_active_in organelle membrane contact site	ISO Inferred from Sequence Orthology more info
is_active_in phagophore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: autophagy-related protein 2 homolog A

Names: ATG2 autophagy related 2 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109545.1 → NP_001103015.1 autophagy-related protein 2 homolog A

See identical proteins and their annotated locations for NP_001103015.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A0A8I6A310, A6HZF8, D3ZT64

Related

ENSRNOP00000073173.1, ENSRNOT00000090100.3

Conserved Domains (2) summary

pfam09333
Location:1817 → 1910

ATG_C; Autophagy-related protein C terminal domain

pfam12624
Location:14 → 111

Chorein_N; N-terminal region of Chorein or VPS13