Rab11fip3 RAB11 family interacting protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab11fip3provided by RGD
Official Full Name: RAB11 family interacting protein 3provided by RGD
Primary source: RGD:1308952
See related: EnsemblRapid:ENSRNOG00000032152 AllianceGenome:RGD:1308952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRRGT00043; RGD1308952
Summary: Predicted to enable several functions, including dynein light intermediate chain binding activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including regulation of intracellular transport; regulation of protein localization; and vesicle-mediated transport to the plasma membrane. Predicted to act upstream of or within protein localization to cilium. Predicted to be located in several cellular components, including Golgi apparatus; centriolar satellite; and cytoplasmic vesicle. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cleavage furrow; cytoplasmic vesicle; and midbody. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 349.4), Brain (RPKM 75.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (15507151..15591173, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (15002650..15086382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15348356..15433384, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BE115524 (e-PCR)
- UniSTS:248171

d10rat183 (e-PCR)
- UniSTS:120687

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adiponectin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cleavage furrow	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rab11 family-interacting protein 3

Names: RAB11 family interacting protein 3 (class II); eferin

NP_001414014.1

EC 2.7.4.6

XP_002727801.1

EC 2.7.4.6

XP_006246133.1

EC 2.7.4.6

XP_038943046.1

EC 2.7.4.6

XP_063125014.1

EC 2.7.4.6

XP_063125015.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427085.1 → NP_001414014.1 rab11 family-interacting protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6GLH8

Related

ENSRNOP00000095174.1, ENSRNOT00000117914.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

15507151..15591173 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246071.4 → XP_006246133.1 rab11 family-interacting protein 3 isoform X2

See identical proteins and their annotated locations for XP_006246133.1

UniProtKB/TrEMBL

A0A8I5ZUA1

Related

ENSRNOP00000082618.1, ENSRNOT00000098691.2

Conserved Domains (7) summary

cd00051
Location:516 → 573

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09457
Location:1013 → 1053

RBD-FIP; FIP domain

pfam05700
Location:776 → 886

BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

pfam07926
Location:837 → 985

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam13499
Location:517 → 573

EF-hand_7; EF-hand domain pair

pfam14077
Location:944 → 987

WD40_alt; Alternative WD40 repeat motif

cl00143
Location:837 → 939

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
XM_002727755.6 → XP_002727801.1 rab11 family-interacting protein 3 isoform X1

See identical proteins and their annotated locations for XP_002727801.1

UniProtKB/TrEMBL

A0A8I5ZQX0

Related

ENSRNOP00000080945.1, ENSRNOT00000100345.2

Conserved Domains (7) summary

cd00051
Location:516 → 573

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09457
Location:1025 → 1065

RBD-FIP; FIP domain

pfam05700
Location:788 → 898

BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

pfam07926
Location:849 → 997

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam13499
Location:517 → 573

EF-hand_7; EF-hand domain pair

pfam14077
Location:956 → 999

WD40_alt; Alternative WD40 repeat motif

cl00143
Location:849 → 951

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
XM_063268945.1 → XP_063125015.1 rab11 family-interacting protein 3 isoform X5

UniProtKB/TrEMBL

F7F3L0, Q66H66

Related

ENSRNOP00000027439.5, ENSRNOT00000027439.5
XM_063268944.1 → XP_063125014.1 rab11 family-interacting protein 3 isoform X3
XM_039087118.2 → XP_038943046.1 rab11 family-interacting protein 3 isoform X4

Conserved Domains (2) summary

PTZ00449
Location:12 → 328

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

pfam13405
Location:516 → 545

EF-hand_6; EF-hand domain