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    Actl7a actin-like 7a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Actl7aprovided by RGD
    Official Full Name
    actin-like 7aprovided by RGD
    Primary source
    RGD:1304697
    See related
    EnsemblRapid:ENSRNOG00000016641 AllianceGenome:RGD:1304697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arp7a; Tact2; T-actin 2
    Summary
    Predicted to be involved in acrosome assembly and fertilization. Part of protein-containing complex. Human ortholog(s) of this gene implicated in male infertility and spermatogenic failure 86. Orthologous to human ACTL7A (actin like 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 419.6) and Adrenal (RPKM 15.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Actl7a in Genome Data Viewer
    Location:
    5q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76242201..76245647)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71447447..71450440)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (73494582..73498012)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553455 Neighboring gene actin-like 7b Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene actin binding transcription modulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody. Fu J, et al. Sci Rep, 2016 Mar 9. PMID 26957350, Free PMC Article
    2. Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder. Afsharpad M, et al. Pathol Oncol Res, 2019 Jan. PMID 29058301
    3. Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are differentially expressed in the cytoplasm and nucleus of mouse haploid germ cells. Tanaka H, et al. Biol Reprod, 2003 Aug. PMID 12672658
    4. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. Boëda B, et al. J Biol Chem, 2011 Apr 1. PMID 21278383, Free PMC Article
    5. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
      Title: Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acrosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-like protein 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011973.1 → NP_001011973.1  actin-like protein 7A

      See identical proteins and their annotated locations for NP_001011973.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082101
      UniProtKB/Swiss-Prot
      Q641W9
      UniProtKB/TrEMBL
      A6KDR3
      Conserved Domains (2) summary
      pfam16840
      Location:6 → 70
      ACTL7A_N; Actin-like protein 7A N-terminus
      cl17037
      Location:72 → 440
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      76242201..76245647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287305.1 → XP_063143375.1  actin-like protein 7A isoform X1

      UniProtKB/Swiss-Prot
      Q641W9
      UniProtKB/TrEMBL
      A6KDR3
      Related
      ENSRNOP00000102903.1, ENSRNOT00000146373.1

    2. XM_008763707.4 → XP_008761929.1  actin-like protein 7A isoform X1

      See identical proteins and their annotated locations for XP_008761929.1

      UniProtKB/Swiss-Prot
      Q641W9
      UniProtKB/TrEMBL
      A6KDR3
      Conserved Domains (2) summary
      pfam16840
      Location:6 → 70
      ACTL7A_N; Actin-like protein 7A N-terminus
      cl17037
      Location:72 → 440
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641W9.1 GenPept UniProtKB/Swiss-Prot:Q641W9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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