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    Epb41l4a erythrocyte membrane protein band 4.1 like 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307514, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Epb41l4aprovided by RGD
    Official Full Name
    erythrocyte membrane protein band 4.1 like 4Aprovided by RGD
    Primary source
    RGD:1306034
    See related
    EnsemblRapid:ENSRNOG00000026050 AllianceGenome:RGD:1306034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Epb4.1l4a
    Summary
    Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be active in cytoskeleton. Orthologous to human EPB41L4A (erythrocyte membrane protein band 4.1 like 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 47.9), Lung (RPKM 35.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epb41l4a in Genome Data Viewer
    Location:
    18p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (25680169..25890998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (25405461..25615392, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (26570051..26788586, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120098269 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene U7 small nuclear RNA Neighboring gene 60S ribosomal protein L23a-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 4A
    Names
    erythrocyte protein band 4.1-like 4a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107397.2 → NP_001100867.1  band 4.1-like protein 4A

      See identical proteins and their annotated locations for NP_001100867.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168858
      UniProtKB/TrEMBL
      B5DEZ0, F1LQE5
      Conserved Domains (3) summary
      cd13186
      Location:23 → 112
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:127 → 171
      FA; FERM adjacent (FA)
      cl09511
      Location:2 → 27
      FERM_B-lobe; FERM domain B-lobe

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      25680169..25890998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277376.1 → XP_063133446.1  band 4.1-like protein 4A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW20
      Related
      ENSRNOP00000104301.1, ENSRNOT00000142918.1

    2. XM_006254584.5 → XP_006254646.1  band 4.1-like protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006254646.1

      UniProtKB/TrEMBL
      A0A0G2JW20, A0A8I6ATD3
      Conserved Domains (5) summary
      smart00295
      Location:13 → 211
      B41; Band 4.1 homologues
      cd13186
      Location:207 → 296
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:105 → 211
      FERM_M; FERM central domain
      pfam08736
      Location:311 → 354
      FA; FERM adjacent (FA)
      pfam09379
      Location:15 → 80
      FERM_N; FERM N-terminal domain

    3. XM_006254583.5 → XP_006254645.1  band 4.1-like protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006254645.1

      UniProtKB/TrEMBL
      A0A0G2JW20, A0A8I6ATD3
      Related
      ENSRNOP00000091694.1, ENSRNOT00000099986.2
      Conserved Domains (5) summary
      smart00295
      Location:13 → 211
      B41; Band 4.1 homologues
      cd13186
      Location:207 → 296
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:105 → 211
      FERM_M; FERM central domain
      pfam08736
      Location:311 → 354
      FA; FERM adjacent (FA)
      pfam09379
      Location:15 → 80
      FERM_N; FERM N-terminal domain

    4. XM_063277377.1 → XP_063133447.1  band 4.1-like protein 4A isoform X3

      UniProtKB/TrEMBL
      B5DEZ0, F1LQE5

    5. XM_039096875.2 → XP_038952803.1  band 4.1-like protein 4A isoform X3

      UniProtKB/TrEMBL
      B5DEZ0, F1LQE5
      Conserved Domains (3) summary
      cd13186
      Location:23 → 112
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:127 → 171
      FA; FERM adjacent (FA)
      cl09511
      Location:2 → 27
      FERM_B-lobe; FERM domain B-lobe
    Nucleotide Protein Strain
    Heading Accession and Version

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