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    Kpna6 karyopherin subunit alpha 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kpna6provided by RGD
    Official Full Name
    karyopherin subunit alpha 6provided by RGD
    Primary source
    RGD:1306570
    See related
    EnsemblRapid:ENSRNOG00000000127 AllianceGenome:RGD:1306570
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule biosynthetic process; and protein import into nucleus. Predicted to be located in cytoplasm and host cell. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 288.6), Kidney (RPKM 271.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kpna6 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147272466..147307523, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141988111..142021483, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147852738..147867600, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351039 Neighboring gene coiled coil domain containing 28B Neighboring gene taxilin alpha Neighboring gene transmembrane protein 39b Neighboring gene KH RNA binding domain containing, signal transduction associated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth. Plant KE, et al. Pharmacogenet Genomics, 2006 Sep. PMID 16906019
    2. H7N9 Influenza A Virus Exhibits Importin-α7-Mediated Replication in the Mammalian Respiratory Tract. Bertram S, et al. Am J Pathol, 2017 Apr. PMID 28189564
    3. Importin α7 is essential for zygotic genome activation and early mouse development. Rother F, et al. PLoS One, 2011 Mar 29. PMID 21479251, Free PMC Article
    4. Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. Sakakida Y, et al. J Biol Chem, 2005 Apr 8. PMID 15689618
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC124892

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maternal process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit alpha-7
    Names
    karyopherin (importin) alpha 6
    karyopherin (importin) alpha 6-like
    karyopherin alpha 6 (importin alpha 7)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015029.2 → NP_001015029.2  importin subunit alpha-7

      See identical proteins and their annotated locations for NP_001015029.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105813
      UniProtKB/TrEMBL
      A0A8I5ZNJ2, Q3KR98
      Related
      ENSRNOP00000079464.1, ENSRNOT00000096749.2
      Conserved Domains (2) summary
      COG5064
      Location:41 → 530
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:259 → 284
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      147272466..147307523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110358.2 → XP_038966286.1  importin subunit alpha-7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZS1, A0A8I5ZNJ2
      Related
      ENSRNOP00000071158.1, ENSRNOT00000087556.3
      Conserved Domains (2) summary
      COG5064
      Location:36 → 525
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:254 → 279
      ARM; armadillo repeat [structural motif]

    2. XM_039110360.2 → XP_038966288.1  importin subunit alpha-7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNJ2, Q56R15
      Conserved Domains (2) summary
      COG5064
      Location:33 → 522
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:251 → 276
      ARM; armadillo repeat [structural motif]

    3. XM_063288025.1 → XP_063144095.1  importin subunit alpha-7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNJ2, Q56R15
    Nucleotide Protein Strain
    Heading Accession and Version

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