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    PHOSPHO2 phosphatase, orphan 2 [ Homo sapiens (human) ]

    Gene ID: 493911, updated on 27-Nov-2024

    Summary

    Official Symbol
    PHOSPHO2provided by HGNC
    Official Full Name
    phosphatase, orphan 2provided by HGNC
    Primary source
    HGNC:HGNC:28316
    See related
    Ensembl:ENSG00000144362 AllianceGenome:HGNC:28316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable phosphatase activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 6.7), prostate (RPKM 5.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PHOSPHO2 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169694469..169701708)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170174071..170181317)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170550979..170558218)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase G Neighboring gene MPRA-validated peak3919 silencer Neighboring gene cilia and flagella associated protein 210 Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12082 Neighboring gene uncharacterized LOC124906089 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Readthrough PHOSPHO2-KLHL23

    Readthrough gene: PHOSPHO2-KLHL23, Included gene: KLHL23

    Clone Names

    • MGC22679, MGC111048

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pyridoxal phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pyridoxal phosphate phosphatase PHOSPHO2
    NP_001008489.1
    NP_001186214.1
    NP_001186215.1
    NP_001186216.1
    NP_001186217.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008489.4NP_001008489.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001008489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000352782.3, ENST00000359744.8
      Conserved Domains (1) summary
      pfam06888
      Location:3239
      Put_Phosphatase; Putative Phosphatase
    2. NM_001199285.2NP_001186214.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186214.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      AK314915, BC106013
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Conserved Domains (1) summary
      pfam06888
      Location:3239
      Put_Phosphatase; Putative Phosphatase
    3. NM_001199286.2NP_001186215.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013, BI550291, DA211528
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000481046.1, ENST00000616524.4
      Conserved Domains (1) summary
      pfam06888
      Location:3239
      Put_Phosphatase; Putative Phosphatase
    4. NM_001199287.2NP_001186216.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186216.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013, BM820383, DA211528
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000481680.1, ENST00000616481.4
      Conserved Domains (1) summary
      pfam06888
      Location:3239
      Put_Phosphatase; Putative Phosphatase
    5. NM_001199288.2NP_001186217.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013, DA211528, DB443540
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000481857.1, ENST00000617738.4
      Conserved Domains (1) summary
      pfam06888
      Location:3239
      Put_Phosphatase; Putative Phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      169694469..169701708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      170174071..170181317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)