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    Iapp islet amyloid polypeptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24476, updated on 4-Jan-2025

    Summary

    Official Symbol
    Iappprovided by RGD
    Official Full Name
    islet amyloid polypeptideprovided by RGD
    Primary source
    RGD:2854
    See related
    EnsemblRapid:ENSRNOG00000082704 AllianceGenome:RGD:2854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables hormone activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; and eating behavior. Predicted to be located in inclusion body. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 24.5), Testes (RPKM 7.6) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Iapp in Genome Data Viewer
    Location:
    4q44
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (176968097..176975363)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175237107..175244373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176509863..176517903)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene solute carrier organic anion transporter family, member 1A5 Neighboring gene uncharacterized LOC102549024 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ like helicase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity PubMed 
    enables hormone activity PubMed 
    enables identical protein binding  
    enables lipid binding  
    enables receptor ligand activity PubMed 
    enables receptor ligand activity  
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in amylin receptor 1 signaling pathway  
    involved_in amylin receptor 2 signaling pathway  
    involved_in amylin receptor 3 signaling pathway  
    involved_in amylin receptor signaling pathway PubMed 
    involved_in amylin receptor signaling pathway PubMed 
    involved_in amylin receptor signaling pathway  
    involved_in amyloid fibril formation  
    acts_upstream_of bone resorption  
    involved_in eating behavior PubMed 
    involved_in glucose metabolic process PubMed 
    acts_upstream_of_or_within negative regulation of bone resorption  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of osteoclast differentiation  
    acts_upstream_of osteoclast differentiation  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of cAMP/PKA signal transduction  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in protein destabilization  
    involved_in protein homooligomerization  
    acts_upstream_of_or_within sensory perception of pain  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in inclusion body  
    located_in neuronal cell body  
    located_in secretory granule PubMed 

    General protein information

    Preferred Names
    islet amyloid polypeptide
    Names
    DAP
    amylin
    diabetes-associated peptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012586.3NP_036718.1  islet amyloid polypeptide preproprotein

      See identical proteins and their annotated locations for NP_036718.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P12969
      UniProtKB/TrEMBL
      A6IMT2
      Related
      ENSRNOP00000099257.1, ENSRNOT00000140283.1
      Conserved Domains (1) summary
      pfam00214
      Location:3677
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      176968097..176975363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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