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    Aprt adenine phosphoribosyl transferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292072, updated on 4-Jan-2025

    Summary

    Official Symbol
    Aprtprovided by RGD
    Official Full Name
    adenine phosphoribosyl transferaseprovided by RGD
    Primary source
    RGD:1307758
    See related
    AllianceGenome:RGD:1307758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables AMP binding activity. Involved in cellular response to insulin stimulus and lactation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 571.1), Lung (RPKM 480.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Aprt in Genome Data Viewer
    Location:
    19q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67534737..67537027, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50626201..50628491, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55387288..55389256, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694354 Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene trafficking protein particle complex subunit 2L

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP binding  
    enables AMP binding PubMed 
    enables AMP binding  
    enables AMP binding  
    enables adenine binding  
    enables adenine binding  
    enables adenine binding  
    enables adenine phosphoribosyltransferase activity  
    enables adenine phosphoribosyltransferase activity  
    enables adenine phosphoribosyltransferase activity  
    enables adenine phosphoribosyltransferase activity  
    Process Evidence Code Pubs
    involved_in AMP salvage  
    involved_in AMP salvage  
    acts_upstream_of_or_within AMP salvage  
    involved_in AMP salvage  
    involved_in GMP salvage  
    involved_in GMP salvage  
    involved_in IMP salvage  
    involved_in IMP salvage  
    acts_upstream_of_or_within adenine metabolic process  
    involved_in adenine salvage  
    involved_in adenine salvage  
    involved_in cellular response to insulin stimulus PubMed 
    involved_in grooming behavior  
    NOT acts_upstream_of_or_within grooming behavior  
    acts_upstream_of_or_within grooming behavior  
    involved_in lactation PubMed 
    involved_in purine ribonucleoside salvage  
    acts_upstream_of_or_within purine ribonucleoside salvage  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    adenine phosphoribosyltransferase
    NP_001013079.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013061.2NP_001013079.1  adenine phosphoribosyltransferase

      See identical proteins and their annotated locations for NP_001013079.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P36972
      UniProtKB/TrEMBL
      A0A8L2QU71, A6IZS8
      Conserved Domains (1) summary
      PRK02304
      Location:6180
      PRK02304; adenine phosphoribosyltransferase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67534737..67537027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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