Bvht braveheart long non-coding RNA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bvhtprovided by MGI
Official Full Name: braveheart long non-coding RNAprovided by MGI
Primary source: MGI:MGI:5434104
See related: Ensembl:ENSMUSG00000098098 AllianceGenome:MGI:5434104
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm20748; Braveheart
Summary: This gene encodes a spliced long non-coding RNA that may play a critical role in cardiovascular lineage commitment. During cardiomyocyte differentiation this transcript interacts with SUZ12, a component of polycomb repressive complex 2 (PRC2) which is known to mediate epigenetic gene silencing. It has been suggested that this transcript functions by activating a network of genes that control cardiovascular cell fate. [provided by RefSeq, Dec 2014]
Expression: Biased expression in bladder adult (RPKM 78.4), subcutaneous fat pad adult (RPKM 10.1) and 4 other tissues See more
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Genomic context

Location:: 18; 18 E1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61772724..61780556)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (61639653..61647485)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro.
Title: Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro.
A G-rich motif in the lncRNA Braveheart interacts with Cnbp to specify the cardiovascular lineage.
Title: A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage.
Study identified Braveheart (Bvht), a heart-associated lncRNA in mouse and show that Bvht is required for progression of nascent mesoderm toward a cardiac fate.
Title: Braveheart, a long noncoding RNA required for cardiovascular lineage commitment.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect cardiac cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.