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    Apoa1 apolipoprotein A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25081, updated on 4-Jan-2025

    Summary

    Official Symbol
    Apoa1provided by RGD
    Official Full Name
    apolipoprotein A1provided by RGD
    Primary source
    RGD:2130
    See related
    EnsemblRapid:ENSRNOG00000045679 AllianceGenome:RGD:2130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    apoA-I
    Summary
    Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including negative regulation of lipase activity; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface and extracellular space. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including artery disease (multiple); major depressive disorder; ocular hypertension; sciatic neuropathy; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 17215.8) See more
    Orthologs
    NEW
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    Genomic context

    See Apoa1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55423945..55425729)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46527251..46529035)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50525091..50526875)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094333 Neighboring gene SIK family kinase 3 Neighboring gene POU class 5 homeobox 1, pseudogene 1 Neighboring gene apolipoprotein C3 Neighboring gene apolipoprotein A4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 38
    Function Evidence Code Pubs
    enables amyloid-beta binding  
    enables amyloid-beta binding PubMed 
    enables amyloid-beta binding  
    enables apolipoprotein A-I receptor binding  
    enables apolipoprotein A-I receptor binding  
    enables apolipoprotein receptor binding  
    enables chemorepellent activity  
    enables chemorepellent activity  
    enables cholesterol binding  
    enables cholesterol binding  
    enables cholesterol transfer activity PubMed 
    enables cholesterol transfer activity  
    contributes_to cholesterol transfer activity  
    enables cholesterol transfer activity  
    enables enzyme binding  
    enables enzyme binding  
    enables heat shock protein binding  
    enables heat shock protein binding  
    enables high-density lipoprotein particle binding  
    enables high-density lipoprotein particle receptor binding  
    enables high-density lipoprotein particle receptor binding  
    enables identical protein binding  
    enables identical protein binding  
    enables lipase inhibitor activity PubMed 
    enables lipid binding  
    enables lipid transporter activity  
    enables lipoprotein particle binding  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phospholipid binding  
    enables phospholipid binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables receptor ligand activity  
    enables signaling receptor binding  
    Items 1 - 25 of 38
    Items 1 - 25 of 105
    Process Evidence Code Pubs
    NOT involved_in ERK1 and ERK2 cascade  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in acylglycerol homeostasis  
    acts_upstream_of_or_within adrenal gland development  
    involved_in animal organ regeneration PubMed 
    NOT acts_upstream_of_or_within axon regeneration  
    acts_upstream_of_or_within blood vessel endothelial cell migration  
    involved_in cellular response to lipoprotein particle stimulus  
    involved_in cellular response to lipoprotein particle stimulus  
    acts_upstream_of_or_within cholesterol biosynthetic process  
    involved_in cholesterol efflux  
    involved_in cholesterol efflux  
    acts_upstream_of_or_within cholesterol efflux  
    involved_in cholesterol efflux  
    involved_in cholesterol homeostasis  
    involved_in cholesterol homeostasis  
    involved_in cholesterol import  
    involved_in cholesterol import  
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    acts_upstream_of_or_within cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    involved_in cholesterol transport PubMed 
    acts_upstream_of_or_within cholesterol transport  
    acts_upstream_of_or_within endothelial cell proliferation  
    acts_upstream_of_or_within glucocorticoid metabolic process  
    involved_in high-density lipoprotein particle assembly  
    involved_in high-density lipoprotein particle assembly  
    involved_in high-density lipoprotein particle remodeling  
    involved_in high-density lipoprotein particle remodeling  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    acts_upstream_of_or_within lipid storage  
    acts_upstream_of_or_within lipoprotein biosynthetic process  
    involved_in lipoprotein metabolic process  
    involved_in negative chemotaxis  
    involved_in negative chemotaxis  
    involved_in negative regulation of cell adhesion molecule production  
    involved_in negative regulation of cell adhesion molecule production  
    involved_in negative regulation of cytokine production involved in immune response  
    involved_in negative regulation of cytokine production involved in immune response  
    involved_in negative regulation of heterotypic cell-cell adhesion  
    involved_in negative regulation of heterotypic cell-cell adhesion  
    acts_upstream_of_or_within negative regulation of hydrolase activity  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of interleukin-1 beta production  
    involved_in negative regulation of interleukin-1 beta production  
    involved_in negative regulation of lipase activity PubMed 
    involved_in negative regulation of response to cytokine stimulus  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in negative regulation of very-low-density lipoprotein particle remodeling  
    involved_in negative regulation of very-low-density lipoprotein particle remodeling  
    involved_in peptidyl-methionine modification  
    involved_in peripheral nervous system axon regeneration PubMed 
    involved_in phosphatidylcholine biosynthetic process  
    involved_in phosphatidylcholine biosynthetic process  
    involved_in phospholipid efflux  
    involved_in phospholipid efflux  
    involved_in phospholipid efflux  
    involved_in phospholipid homeostasis  
    involved_in phospholipid homeostasis  
    acts_upstream_of_or_within phospholipid metabolic process  
    involved_in phospholipid transport PubMed 
    involved_in positive regulation of CoA-transferase activity  
    involved_in positive regulation of Rho protein signal transduction  
    involved_in positive regulation of Rho protein signal transduction  
    involved_in positive regulation of cholesterol efflux  
    involved_in positive regulation of cholesterol efflux  
    involved_in positive regulation of cholesterol efflux  
    involved_in positive regulation of cholesterol metabolic process  
    involved_in positive regulation of cholesterol metabolic process  
    involved_in positive regulation of hydrolase activity  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phospholipid efflux  
    involved_in positive regulation of phospholipid efflux  
    involved_in positive regulation of phospholipid efflux  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    acts_upstream_of_or_within positive regulation of transferase activity  
    NOT acts_upstream_of_or_within protein localization  
    involved_in protein oxidation  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of Cdc42 protein signal transduction  
    involved_in regulation of Cdc42 protein signal transduction  
    acts_upstream_of_or_within regulation of intestinal cholesterol absorption  
    acts_upstream_of_or_within regulation of protein phosphorylation  
    involved_in response to estrogen PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in reverse cholesterol transport  
    involved_in reverse cholesterol transport  
    NOT involved_in transforming growth factor beta receptor signaling pathway  
    involved_in triglyceride homeostasis  
    involved_in triglyceride homeostasis  
    involved_in vitamin transport  
    involved_in vitamin transport  
    Items 1 - 25 of 105
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    part_of chylomicron  
    located_in cytoplasmic vesicle  
    part_of discoidal high-density lipoprotein particle PubMed 
    located_in endocytic vesicle  
    located_in endocytic vesicle  
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular vesicle  
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle PubMed 
    part_of high-density lipoprotein particle  
    part_of intermediate-density lipoprotein particle PubMed 
    part_of low-density lipoprotein particle  
    part_of low-density lipoprotein particle PubMed 
    part_of spherical high-density lipoprotein particle  
    part_of spherical high-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    apolipoprotein A-I
    Names
    apo-AI
    apolipoprotein A-1
    preproapolipoprotein A-I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012738.2NP_036870.1  apolipoprotein A-I preproprotein

      See identical proteins and their annotated locations for NP_036870.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O08877, O09054, P04639, Q5EBB2
      UniProtKB/TrEMBL
      A0A0G2JU23
      Related
      ENSRNOP00000065206.1, ENSRNOT00000074357.4
      Conserved Domains (1) summary
      pfam01442
      Location:73236
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55423945..55425729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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