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    Gp6 glycoprotein 6 platelet [ Mus musculus (house mouse) ]

    Gene ID: 243816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gp6provided by MGI
    Official Full Name
    glycoprotein 6 plateletprovided by MGI
    Primary source
    MGI:MGI:1889810
    See related
    Ensembl:ENSMUSG00000078810 AllianceGenome:MGI:1889810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpvi; Gm469; 9830166G18Rik
    Summary
    Enables collagen binding activity and collagen receptor activity. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway; peptidyl-tyrosine phosphorylation; and platelet aggregation. Located in cell surface and plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog(s) of this gene implicated in blood platelet disease (multiple); coronary artery disease (multiple); and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gp6 in Genome Data Viewer
    Location:
    7 A1; 7 2.52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4365852..4400849, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4362853..4397851, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15931 Neighboring gene STARR-seq mESC enhancer starr_17925 Neighboring gene STARR-seq mESC enhancer starr_17927 Neighboring gene STARR-seq mESC enhancer starr_17928 Neighboring gene STARR-seq mESC enhancer starr_17929 Neighboring gene STARR-seq mESC enhancer starr_17930 Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1718 Neighboring gene STARR-positive B cell enhancer ABC_E9682 Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Lockyer S, et al. Thromb Res, 2006. PMID 16139873
    2. Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models. Jain S, et al. J Thromb Haemost, 2009 Oct. PMID 19624454
    3. Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria. Claushuis TAM, et al. Blood, 2018 Feb 22. PMID 29187378
    4. GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice. Gupta S, et al. Blood, 2018 Mar 8. PMID 29295843, Free PMC Article
    5. The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Cheli Y, et al. Blood, 2008 Feb 1. PMID 17991808, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.
      Title: Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.
    2. Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.
      Title: Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.
    3. A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
      Title: A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
    4. Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.
      Title: Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.
    5. Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.
      Title: Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.
    6. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of beta-amyloid.
      Title: The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
    7. Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets.
      Title: Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets.
    8. Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
      Title: Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
    9. Our results show that, contrary to defects in coagulation, bleeding following a loss of vascular integrity caused by platelet CLEC-2 and GPVI deficiency facilitates wound repair by increasing fibrin(ogen) deposition, reducing inflammation, and promoting angiogenesis.
      Title: Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice.
    10. the truncated CD45 isoform regulates GPVI-mediated signaling and platelet functional responses by regulating SFK activation
      Title: Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables collagen receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within collagen-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within platelet aggregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tetraspanin-enriched microdomain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in tetraspanin-enriched microdomain ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    platelet glycoprotein VI
    Names
    glycoprotein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163014.1 → NP_001156486.1  platelet glycoprotein VI precursor

      See identical proteins and their annotated locations for NP_001156486.1

      Status: VALIDATED

      Source sequence(s)
      AC137969
      Consensus CDS
      CCDS51972.1
      UniProtKB/Swiss-Prot
      E9QPN2, P0C191
      UniProtKB/TrEMBL
      B2RR15
      Related
      ENSMUSP00000145740.2, ENSMUST00000206928.2
      Conserved Domains (2) summary
      smart00410
      Location:34 → 96
      IG_like; Immunoglobulin like
      cl11960
      Location:27 → 109
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4365852..4400849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539910.4 → XP_006539973.1  platelet glycoprotein VI isoform X2

      Conserved Domains (1) summary
      cl11960
      Location:16 → 105
      Ig; Immunoglobulin domain

    2. XM_006539909.4 → XP_006539972.1  platelet glycoprotein VI isoform X1

      UniProtKB/TrEMBL
      A0A140T8Q7
      Conserved Domains (1) summary
      cl11960
      Location:114 → 203
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C191.2 GenPept UniProtKB/Swiss-Prot:P0C191

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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