Ppil3 peptidylprolyl isomerase (cyclophilin)-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppil3provided by MGI
Official Full Name: peptidylprolyl isomerase (cyclophilin)-like 3provided by MGI
Primary source: MGI:MGI:1917475
See related: Ensembl:ENSMUSG00000026035 AllianceGenome:MGI:1917475
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp10l; 2310076N22Rik; 2510026K04Rik
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPIL3 (peptidylprolyl isomerase like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 5.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.3; 1 29.1 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (58470152..58484878, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (58430993..58445591, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase-like 3

Names: PPIase; cyclophilin-like 3; cyclophilin-like protein PPIL3; rotamase PPIL3

NP_001272755.1

EC 5.2.1.8

NP_001272756.1

EC 5.2.1.8

NP_081627.1

EC 5.2.1.8

NP_081650.2

EC 5.2.1.8

XP_011236892.1

EC 5.2.1.8

XP_011236893.1

EC 5.2.1.8

XP_011236894.1

EC 5.2.1.8

XP_011236895.1

EC 5.2.1.8

XP_011236896.1

EC 5.2.1.8

XP_011236897.1

EC 5.2.1.8

XP_011236898.1

EC 5.2.1.8

XP_030098742.1

EC 5.2.1.8

XP_030098746.1

EC 5.2.1.8

XP_030098748.1

EC 5.2.1.8

XP_030098751.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285826.1 → NP_001272755.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform 1

See identical proteins and their annotated locations for NP_001272755.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest variant and encodes the longest isoform (1). Variants 1, 3, and 4 encode the same protein.

Source sequence(s)

AK010207, BB687332, CJ170065, DV043111

Consensus CDS

CCDS35579.1

UniProtKB/Swiss-Prot

Q812D2, Q9CY23, Q9D6L8

Related

ENSMUSP00000112947.2, ENSMUST00000117069.8

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
NM_001285827.1 → NP_001272756.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform 1

See identical proteins and their annotated locations for NP_001272756.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1, 3, and 4 encode the same isoform (1).

Source sequence(s)

AK010207, BB687332, CJ166559

Consensus CDS

CCDS35579.1

UniProtKB/Swiss-Prot

Q812D2, Q9CY23, Q9D6L8

Related

ENSMUSP00000109988.2, ENSMUST00000114348.8

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
NM_027351.3 → NP_081627.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform 1

See identical proteins and their annotated locations for NP_081627.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 3, and 4 encode the same isoform (1).

Source sequence(s)

AK010207, BB687332, BC060993

Consensus CDS

CCDS35579.1

UniProtKB/Swiss-Prot

Q812D2, Q9CY23, Q9D6L8

Related

ENSMUSP00000080378.6, ENSMUST00000081677.12

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
NM_027374.3 → NP_081650.2 peptidyl-prolyl cis-trans isomerase-like 3 isoform 2

See identical proteins and their annotated locations for NP_081650.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC121091, AK010207, AK011000, BB844274, BY288296

Consensus CDS

CCDS35580.1

UniProtKB/Swiss-Prot

Q9D6L8

Related

ENSMUSP00000109984.3, ENSMUST00000114345.9

Conserved Domains (1) summary

cd01928
Location:1 → 120

Cyclophilin_PPIL3_like; Cyclophilin_PPIL3_like. Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

58470152..58484878 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242882.2 → XP_030098742.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q812D2, Q9CY23, Q9D6L8

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_030242886.2 → XP_030098746.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q812D2, Q9CY23, Q9D6L8

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_030242891.2 → XP_030098751.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X4

Conserved Domains (1) summary

cl00197
Location:1 → 105

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_030242888.2 → XP_030098748.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q812D2, Q9CY23, Q9D6L8

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_011238594.4 → XP_011236896.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

See identical proteins and their annotated locations for XP_011236896.1

Conserved Domains (1) summary

cd01928
Location:1 → 122

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_011238596.4 → XP_011236898.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X3

Conserved Domains (1) summary

cl00197
Location:1 → 73

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_011238593.4 → XP_011236895.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

See identical proteins and their annotated locations for XP_011236895.1

Conserved Domains (1) summary

cd01928
Location:1 → 122

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_011238592.4 → XP_011236894.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

See identical proteins and their annotated locations for XP_011236894.1

Conserved Domains (1) summary

cd01928
Location:1 → 122

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_011238591.4 → XP_011236893.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

See identical proteins and their annotated locations for XP_011236893.1

Conserved Domains (1) summary

cd01928
Location:1 → 122

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_011238595.4 → XP_011236897.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

See identical proteins and their annotated locations for XP_011236897.1

Conserved Domains (1) summary

cd01928
Location:1 → 122

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_011238590.4 → XP_011236892.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

See identical proteins and their annotated locations for XP_011236892.1

Conserved Domains (1) summary

cd01928
Location:1 → 122

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...