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    Ccnq cyclin Q [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303321, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccnqprovided by RGD
    Official Full Name
    cyclin Qprovided by RGD
    Primary source
    RGD:1305651
    See related
    AllianceGenome:RGD:1305651
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam58a; Fam58b; RGD1305651
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase activator activity. Predicted to be involved in regulation of cell cycle G2/M phase transition. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndactyly-telecanthus-anogenital and renal malformations syndrome. Orthologous to human CCNQ (cyclin Q). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Ccnq in Genome Data Viewer
    Location:
    10q25
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (64144560..64145723, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63646532..63647695, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (66019519..66020682, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene nemo like kinase Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like Neighboring gene LYR motif containing 9 like 1 Neighboring gene LYR motif containing 9 Neighboring gene uncharacterized LOC120095150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Guen VJ, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218572, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-Q
    Names
    CDK10-activating cyclin
    cyclin-M
    cyclin-related protein FAM58A
    family with sequence similarity 58, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025412.1 → NP_001020583.1  cyclin-Q

      See identical proteins and their annotated locations for NP_001020583.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097941
      UniProtKB/Swiss-Prot
      Q4QQW5, Q5RJY7
      UniProtKB/TrEMBL
      A6HH70
      Conserved Domains (2) summary
      cd20534
      Location:29 → 137
      CYCLIN_CCNM_CCNQ_rpt1; first cyclin box found in cyclin-M (CCNM) family
      cd20535
      Location:142 → 245
      CYCLIN_CCNM_CCNQ_rpt2; second cyclin box found in cyclin-M (CCNM) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      64144560..64145723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQW5.1 GenPept UniProtKB/Swiss-Prot:Q4QQW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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