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    Ube2m ubiquitin-conjugating enzyme E2M [ Mus musculus (house mouse) ]

    Gene ID: 22192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ube2mprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Mprovided by MGI
    Primary source
    MGI:MGI:108278
    See related
    Ensembl:ENSMUSG00000005575 AllianceGenome:MGI:108278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBC12; Ubc-rs2; 2510040H03Rik
    Summary
    Predicted to enable NEDD8 transferase activity and ubiquitin-protein transferase activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human UBE2M (ubiquitin conjugating enzyme E2 M). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 97.2), whole brain E14.5 (RPKM 66.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2m in Genome Data Viewer
    Location:
    7 A1; 7 7.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12769047..12772202, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13035120..13038275, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6512 Neighboring gene predicted gene, 31649 Neighboring gene tripartite motif-containing 28 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13619992-13620293 Neighboring gene charged multivesicular body protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E6513 Neighboring gene myeloid zinc finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E2223 Neighboring gene STARR-seq mESC enhancer starr_18069 Neighboring gene vomeronasal 1 receptor 85

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders. Lu X, et al. Cell Metab, 2023 Aug 8. PMID 37343564
    2. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Wu D, et al. Nat Commun, 2022 May 31. PMID 35641500, Free PMC Article
    3. Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2. McCormack RM, et al. Elife, 2015 Sep 29. PMID 26418746, Free PMC Article
    4. Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition. Vogl AM, et al. Nat Neurosci, 2015 Feb. PMID 25581363
    5. Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice. Pawlowski TL, et al. Genomics, 2009 Sep. PMID 19501643, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
      Title: UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
    2. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.
      Title: The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.
    3. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
      Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (3) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25453, MGC37197

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NEDD8 transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NEDD8 transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of postsynapse assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD8-conjugating enzyme Ubc12
    Names
    NEDD8 carrier protein
    NEDD8 protein ligase
    UBC12 homolog, yeast
    ubiquitin C, related sequence 2
    NP_001161941.1
    NP_001230897.1
    NP_663553.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168469.2 → NP_001161941.1  NEDD8-conjugating enzyme Ubc12 isoform 2

      See identical proteins and their annotated locations for NP_001161941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS52024.1
      UniProtKB/TrEMBL
      G5E919
      Related
      ENSMUSP00000132604.3, ENSMUST00000165394.9
      Conserved Domains (1) summary
      pfam00179
      Location:2 → 71
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001243968.1 → NP_001230897.1  NEDD8-conjugating enzyme Ubc12 isoform 3

      See identical proteins and their annotated locations for NP_001230897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121301
      UniProtKB/TrEMBL
      F7CDT0
      Related
      ENSMUSP00000122638.2, ENSMUST00000125964.8
      Conserved Domains (1) summary
      pfam00179
      Location:7 → 138
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_145578.3 → NP_663553.1  NEDD8-conjugating enzyme Ubc12 isoform 1

      See identical proteins and their annotated locations for NP_663553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS20825.1
      UniProtKB/Swiss-Prot
      P61082
      UniProtKB/TrEMBL
      F7CDT0
      Related
      ENSMUSP00000005714.8, ENSMUST00000005714.14
      Conserved Domains (1) summary
      pfam00179
      Location:33 → 168
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12769047..12772202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61082.1 GenPept UniProtKB/Swiss-Prot:P61082

    Gene LinkOut

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