Ptrh1 peptidyl-tRNA hydrolase 1 homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptrh1provided by MGI
Official Full Name: peptidyl-tRNA hydrolase 1 homologprovided by MGI
Primary source: MGI:MGI:1913779
See related: Ensembl:ENSMUSG00000053746 AllianceGenome:MGI:1913779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTH; 2210013M04Rik
Summary: Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be involved in rescue of stalled ribosome. Located in mitochondrion. Orthologous to human PTRH1 (peptidyl-tRNA hydrolase 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 12.2), small intestine adult (RPKM 12.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32665760..32667609)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32775748..32778708)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment.
Title: High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493090

AW046744 (e-PCR)
- UniSTS:164155

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminoacyl-tRNA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminoacyl-tRNA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables aminoacyl-tRNA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: probable peptidyl-tRNA hydrolase

NP_848710.1

EC 3.1.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178595.4 → NP_848710.1 probable peptidyl-tRNA hydrolase

See identical proteins and their annotated locations for NP_848710.1

Status: VALIDATED

Source sequence(s)

AL772271

Consensus CDS

CCDS15931.1

UniProtKB/Swiss-Prot

Q8BW00

Related

ENSMUSP00000068850.6, ENSMUST00000066352.6

Conserved Domains (1) summary

cd00462
Location:22 → 193

PTH; Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through ...