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    Dhx40 DEAH-box helicase 40 [ Mus musculus (house mouse) ]

    Gene ID: 67487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhx40provided by MGI
    Official Full Name
    DEAH-box helicase 40provided by MGI
    Primary source
    MGI:MGI:1914737
    See related
    Ensembl:ENSMUSG00000018425 AllianceGenome:MGI:1914737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAD; DDX40; ARG147; 2410016C14Rik
    Summary
    Predicted to enable RNA binding activity and helicase activity. Is expressed in several structures, including adrenal gland; brain; gut; skeletal muscle tissue; and trigeminal nerve. Orthologous to human DHX40 (DEAH-box helicase 40). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 11.1), testis adult (RPKM 10.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx40 in Genome Data Viewer
    Location:
    11 C; 11 51.82 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86659675..86698695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86768849..86807877, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30275 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene clathrin heavy chain Neighboring gene STARR-positive B cell enhancer ABC_E3989 Neighboring gene STARR-positive B cell enhancer ABC_E7036 Neighboring gene STARR-seq mESC enhancer starr_30277 Neighboring gene predicted gene, 42085 Neighboring gene STARR-seq mESC enhancer starr_30279 Neighboring gene STARR-positive B cell enhancer ABC_E7037 Neighboring gene predicted gene, 33742 Neighboring gene STARR-seq mESC enhancer starr_30281 Neighboring gene microRNA 12182 Neighboring gene predicted gene, 38942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DHX40
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 40
    DEAH box protein 40
    NP_080467.3
    XP_017170207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026191.2 → NP_080467.3  probable ATP-dependent RNA helicase DHX40

      See identical proteins and their annotated locations for NP_080467.3

      Status: VALIDATED

      Source sequence(s)
      AK010512, BP771378, BY329362, CF749423
      Consensus CDS
      CCDS36268.1
      UniProtKB/Swiss-Prot
      Q6PE54, Q8BPH2, Q8CD88, Q9CWN3
      Related
      ENSMUSP00000018569.7, ENSMUST00000018569.14
      Conserved Domains (5) summary
      smart00490
      Location:312 → 399
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:48 → 236
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:469 → 557
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:78 → 213
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:591 → 699
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86659675..86698695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314718.3 → XP_017170207.1  probable ATP-dependent RNA helicase DHX40 isoform X1

      Conserved Domains (1) summary
      COG1643
      Location:125 → 636
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PE54.1 GenPept UniProtKB/Swiss-Prot:Q6PE54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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