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    Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) [ Mus musculus (house mouse) ]

    Gene ID: 14810, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grin1provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, NMDA1 (zeta 1)provided by MGI
    Primary source
    MGI:MGI:95819
    See related
    Ensembl:ENSMUSG00000026959 AllianceGenome:MGI:95819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NR1; GluN1; Nmdar; NMD-R1; NMDAR1; M100174; Rgsc174; GluRzeta1; GluRdelta1
    Summary
    Enables several functions, including calmodulin binding activity; cation binding activity; and monoatomic ion channel activity. Involved in calcium ion transmembrane transport and propylene metabolic process. Acts upstream of or within several processes, including chemical synaptic transmission; learning or memory; and regulation of neuron projection development. Located in several cellular components, including postsynaptic density; postsynaptic membrane; and synaptic vesicle membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 73.7), frontal lobe adult (RPKM 72.0) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Grin1 in Genome Data Viewer
    Location:
    2 A3; 2 17.14 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25181189..25209199, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25291177..25319187, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 2 Neighboring gene transmembrane protein 210 Neighboring gene leucine rich repeat containing 26 Neighboring gene glutamate receptor, ionotropic, NMDA1 (zeta 1), opposite strand Neighboring gene STARR-seq mESC enhancer starr_03964 Neighboring gene STARR-seq mESC enhancer starr_03965 Neighboring gene expressed sequence AA543186 Neighboring gene mannosidase, alpha, class 1B, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (27)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to NMDA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NMDA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NMDA glutamate receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables NMDA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to NMDA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NMDA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    contributes_to calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate-gated calcium ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate-gated calcium ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutamate-gated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glycine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables monoatomic cation channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion transmembrane import into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within conditioned taste aversion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic cation transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within monoatomic cation transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pons maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Schwann cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within prepulse inhibition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in propylene metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein localization to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell communication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of monoatomic cation transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuronal synaptic plasticity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of respiratory gaseous exchange IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to amphetamine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glycine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rhythmic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within suckling behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NMDA selective glutamate receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of NMDA selective glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NMDA selective glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic branch ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of neurotransmitter receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    glutamate receptor ionotropic, NMDA 1
    Names
    N-methyl-D-aspartate receptor subunit NR1
    glutamate [NMDA] receptor subunit zeta-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177656.2NP_001171127.1  glutamate receptor ionotropic, NMDA 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional in-frame exon in the 5' coding region, and lacks an exon and contains an alternate 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (2) has distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI844150, AK158175, BC039157, CD355382
      Consensus CDS
      CCDS50529.1
      UniProtKB/TrEMBL
      A2AI16, Q3TZ31
      Related
      ENSMUSP00000109956.4, ENSMUST00000114317.10
      Conserved Domains (5) summary
      cd06379
      Location:8404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42378
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    2. NM_001177657.2NP_001171128.1  glutamate receptor ionotropic, NMDA 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001171128.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon and contains an alternate 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (3) has distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI844150, BC039157, CD355382
      Consensus CDS
      CCDS50528.1
      UniProtKB/TrEMBL
      Q3TZ31
      Related
      ENSMUSP00000109951.2, ENSMUST00000114312.2
      Conserved Domains (5) summary
      cd06379
      Location:8383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42357
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    3. NM_001372558.1NP_001359487.1  glutamate receptor ionotropic, NMDA 1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732309
      Consensus CDS
      CCDS89447.1
      UniProtKB/TrEMBL
      A2AI21
      Related
      ENSMUSP00000109949.4, ENSMUST00000114310.10
      Conserved Domains (4) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam07885
      Location:622677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    4. NM_001372559.1NP_001359488.1  glutamate receptor ionotropic, NMDA 1 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732309
      Consensus CDS
      CCDS89446.1
      UniProtKB/TrEMBL
      A2AI14
      Related
      ENSMUSP00000109957.4, ENSMUST00000114318.10
      Conserved Domains (4) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam07885
      Location:622677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    5. NM_001372560.1NP_001359489.1  glutamate receptor ionotropic, NMDA 1 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732309
      Consensus CDS
      CCDS89445.1
      UniProtKB/TrEMBL
      A2AI20, Q3TZ31
      Related
      ENSMUSP00000109947.4, ENSMUST00000114308.10
      Conserved Domains (4) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam07885
      Location:622677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    6. NM_001372561.1NP_001359490.1  glutamate receptor ionotropic, NMDA 1 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732309
      Consensus CDS
      CCDS89444.1
      UniProtKB/TrEMBL
      A2AI17, Q3TZ31
      Related
      ENSMUSP00000109953.4, ENSMUST00000114314.10
      Conserved Domains (4) summary
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam07885
      Location:601656
      Ion_trans_2; Ion channel
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      cd06379
      Location:25383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    7. NM_001372562.1NP_001359491.1  glutamate receptor ionotropic, NMDA 1 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732309
      Consensus CDS
      CCDS89443.1
      UniProtKB/TrEMBL
      A2AI19, Q3TZ31
      Related
      ENSMUSP00000109946.2, ENSMUST00000114307.8
      Conserved Domains (4) summary
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam07885
      Location:601656
      Ion_trans_2; Ion channel
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      cd06379
      Location:25383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    8. NM_008169.3NP_032195.1  glutamate receptor ionotropic, NMDA 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AI844150, AW494928, BC039157, CD355382, CD363997
      Consensus CDS
      CCDS15764.1
      UniProtKB/Swiss-Prot
      A2AI15, A2AI18, P35438, Q8CFS4
      Related
      ENSMUSP00000028335.7, ENSMUST00000028335.13
      Conserved Domains (6) summary
      cd06379
      Location:8383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42357
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:602656
      Ion_trans_2; Ion channel
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25181189..25209199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)