NTRK2 neurotrophic receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTRK2provided by HGNC
Official Full Name: neurotrophic receptor tyrosine kinase 2provided by HGNC
Primary source: HGNC:HGNC:8032
See related: Ensembl:ENSG00000148053 MIM:600456; AllianceGenome:HGNC:8032
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB
Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression: Biased expression in brain (RPKM 64.6), thyroid (RPKM 30.4) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q21.33

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (84668522..85027054)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (96818888..97177857)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (87283437..87641969)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.
Title: Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.
Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.
Title: Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.
Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
Title: Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.
Title: TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.
Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder.
Title: Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder.
miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.
Title: miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
Title: DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma.
Title: TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma.
BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.
Title: BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.
Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.
Title: Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.

Submit: New GeneRIF Correction See all GeneRIFs (302)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Developmental and epileptic encephalopathy, 58 MedGen: C4693367 OMIM: 617830 GeneReviews: Not available	Compare labs
Obesity, hyperphagia, and developmental delay MedGen: C3151303 OMIM: 613886 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed
Variants close to NTRK2 gene are associated with birth weight in female twins. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G20354 (e-PCR)
- UniSTS:63489

D9S1033E (e-PCR)
- UniSTS:55042

A005N29 (e-PCR)
- UniSTS:63490

G60096 (e-PCR)
- UniSTS:137225

D9S1131 (e-PCR)
- UniSTS:23

G43552 (e-PCR)
- UniSTS:95006

SHGC-12933 (e-PCR)
- UniSTS:60451

SHGC-78112 (e-PCR)
- UniSTS:101683

G60005 (e-PCR)
- UniSTS:137273

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:260424

SHGC-146793 (e-PCR)
- UniSTS:175434

SHGC-104995 (e-PCR)
- UniSTS:169046

RH123603 (e-PCR)
- UniSTS:136023

AFMB335WB1 (e-PCR)
- UniSTS:72024

WI-14821 (e-PCR)
- UniSTS:20328

A008W23 (e-PCR)
- UniSTS:36976

SHGC-146862 (e-PCR)
- UniSTS:175479

RH122554 (e-PCR)
- UniSTS:138618

G15862 (e-PCR)
- UniSTS:59770

WIAF-2133 (e-PCR)
- UniSTS:32129

G20302 (e-PCR)
- UniSTS:10640

A005L08 (e-PCR)
- UniSTS:10641

D9S185E (e-PCR)
- UniSTS:147358

D9S1764 (e-PCR)
- UniSTS:56997

SHGC-142847 (e-PCR)
- UniSTS:171694

RH46089 (e-PCR)
- UniSTS:23487

RH93005 (e-PCR)
- UniSTS:89280

RH102635 (e-PCR)
- UniSTS:96969

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:265675

SHGC-32034 (e-PCR)
- UniSTS:58842

A004Y44 (e-PCR)
- UniSTS:27371

A006U15 (e-PCR)
- UniSTS:7664

D9S1063E (e-PCR)
- UniSTS:151280

RH1565 (e-PCR)
- UniSTS:86261

RH122860 (e-PCR)
- UniSTS:135158

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables brain-derived neurotrophic factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables brain-derived neurotrophic factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables brain-derived neurotrophic factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotrophin binding	IDA Inferred from Direct Assay more info	PubMed
enables neurotrophin binding	ISS Inferred from Sequence or Structural Similarity more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system neuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mechanoreceptor differentiation	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination in peripheral nervous system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of amyloid-beta formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal action potential propagation	IEA Inferred from Electronic Annotation more info
involved_in neurotrophin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in peripheral nervous system neuron development	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal rod cell development	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BDNF/NT-3 growth factors receptor

Names: BDNF-tropomyosine receptor kinase B; neurotrophic tyrosine kinase receptor type 2; tropomyosin-related kinase B; tyrosine kinase receptor B

NP_001007098.1

EC 2.7.10.1

NP_001018074.1

EC 2.7.10.1

NP_001018075.1

EC 2.7.10.1

NP_001018076.1

EC 2.7.10.1

NP_001278866.1

EC 2.7.10.1

NP_001356461.1

EC 2.7.10.1

NP_001356462.1

EC 2.7.10.1

NP_001356463.1

EC 2.7.10.1

NP_001356464.1

EC 2.7.10.1

NP_001356465.1

EC 2.7.10.1

NP_001356466.1

EC 2.7.10.1

NP_001356467.1

EC 2.7.10.1

NP_001356468.1

EC 2.7.10.1

NP_001356469.1

EC 2.7.10.1

NP_001356470.1

EC 2.7.10.1

NP_001356471.1

EC 2.7.10.1

NP_001356472.1

EC 2.7.10.1

NP_001356473.1

EC 2.7.10.1

NP_001356474.1

EC 2.7.10.1

NP_001356475.1

EC 2.7.10.1

NP_001356476.1

EC 2.7.10.1

NP_001356477.1

EC 2.7.10.1

NP_001356478.1

EC 2.7.10.1

NP_001356479.1

EC 2.7.10.1

NP_001356480.1

EC 2.7.10.1

NP_001356481.1

EC 2.7.10.1

NP_006171.2

EC 2.7.10.1

XP_005252058.1

EC 2.7.10.1

XP_005252060.1

EC 2.7.10.1

XP_005252061.1

EC 2.7.10.1

XP_011517020.1

EC 2.7.10.1

XP_016870240.1

EC 2.7.10.1

XP_016870241.1

EC 2.7.10.1

XP_016870242.1

EC 2.7.10.1

XP_016870244.1

EC 2.7.10.1

XP_016870249.1

EC 2.7.10.1

XP_047279388.1

EC 2.7.10.1

XP_047279389.1

EC 2.7.10.1

XP_054218993.1

EC 2.7.10.1

XP_054218994.1

EC 2.7.10.1

XP_054218995.1

EC 2.7.10.1

XP_054218996.1

EC 2.7.10.1

XP_054218997.1

EC 2.7.10.1

XP_054218998.1

EC 2.7.10.1

XP_054218999.1

EC 2.7.10.1

XP_054219000.1

EC 2.7.10.1

XP_054219001.1

EC 2.7.10.1

XP_054219002.1

EC 2.7.10.1

XP_054219003.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012201.2 RefSeqGene

Range

6179..363504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001007097.3 → NP_001007098.1 BDNF/NT-3 growth factors receptor isoform b precursor

See identical proteins and their annotated locations for NP_001007098.1

Status: REVIEWED

Description

Transcript Variant: This variant (b, also known as TrkB-T1) lacks several 3' exons but contains an alternate 3' terminal exon (exon 16 in PMID:11798182), and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants b and o-w all encode the same isoform (b).

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000508622.1, ENST00000692506.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001018064.3 → NP_001018074.1 BDNF/NT-3 growth factors receptor isoform c precursor

See identical proteins and their annotated locations for NP_001018074.1

Status: REVIEWED

Description

Transcript Variant: This variant (c) lacks an alternate in-frame exon in the central coding region, compared to variant a, resulting in an isoform (c) that is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants c, k, and l all encode the same isoform (c).

Source sequence(s)

AL390777, AL445532, AL596132

Consensus CDS

CCDS35050.1

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

A0A8I5KVH8, Q548C2

Conserved Domains (6) summary

cd05093
Location:532 → 819

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001018065.2 → NP_001018075.1 BDNF/NT-3 growth factors receptor isoform d precursor

See identical proteins and their annotated locations for NP_001018075.1

Status: REVIEWED

Description

Transcript Variant: This variant (d) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (d, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants d and m both encode the same isoform (d).

Source sequence(s)

AB209118, AF410901, AL596132

Consensus CDS

CCDS35051.1

UniProtKB/TrEMBL

A0A8I5KUV8

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001018066.3 → NP_001018076.1 BDNF/NT-3 growth factors receptor isoform e precursor

See identical proteins and their annotated locations for NP_001018076.1

Status: REVIEWED

Description

Transcript Variant: This variant (e) lacks an alternate in-frame exon in the central coding region, and also lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (e, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants e and n both encode the same isoform (e).

Source sequence(s)

AL390777, AL596132

Consensus CDS

CCDS35052.1

UniProtKB/TrEMBL

A0A8I5KUV8

Related

ENSP00000365381.1, ENST00000376208.6

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001291937.2 → NP_001278866.1 BDNF/NT-3 growth factors receptor isoform f precursor

Status: REVIEWED

Description

Transcript Variant: This variant (f) uses an alternate in-frame splice site in the central coding region, and lacks several 3' exons but contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a. Variants f and x both encode the same isoform (f).

Source sequence(s)

AL390777

Consensus CDS

CCDS94428.1

UniProtKB/TrEMBL

A0A8I5KR47, A0A8I5QKP8

Related

ENSP00000510356.1, ENST00000686542.1

Conserved Domains (6) summary

cd05855
Location:288 → 366

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

cl15307
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

pfam07679
Location:205 → 283

I-set; Immunoglobulin I-set domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat
NM_001369532.1 → NP_001356461.1 BDNF/NT-3 growth factors receptor isoform c precursor

Status: REVIEWED

Description

Transcript Variant: This variant (k), as well as variants c and l, encodes isoform c.

Source sequence(s)

AL390777, AL445532, AL596132

Consensus CDS

CCDS35050.1

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

A0A8I5KVH8, Q548C2

Related

ENSP00000509743.1, ENST00000686259.1

Conserved Domains (6) summary

cd05093
Location:532 → 819

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369533.1 → NP_001356462.1 BDNF/NT-3 growth factors receptor isoform c precursor

Status: REVIEWED

Description

Transcript Variant: This variant (l), as well as variants c and k, encodes isoform c.

Source sequence(s)

AL390777, AL445532, AL596132

Consensus CDS

CCDS35050.1

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

A0A8I5KVH8, Q548C2

Related

ENSP00000365386.1, ENST00000376213.6

Conserved Domains (6) summary

cd05093
Location:532 → 819

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369534.1 → NP_001356463.1 BDNF/NT-3 growth factors receptor isoform g precursor

Status: REVIEWED

Source sequence(s)

AL390777, AL445532, AL596132

Consensus CDS

CCDS94427.1

UniProtKB/TrEMBL

A0A8I5KVH8, A0A8J8YUT9

Related

ENSP00000314586.5, ENST00000323115.11

Conserved Domains (5) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

cd05093
Location:520 → 807

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

pfam07679
Location:205 → 283

I-set; Immunoglobulin I-set domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat
NM_001369535.1 → NP_001356464.1 BDNF/NT-3 growth factors receptor isoform i

Status: REVIEWED

Source sequence(s)

AL390777, AL445532, AL596132

Consensus CDS

CCDS94431.1

UniProtKB/TrEMBL

A0A8I5KZB7

Related

ENSP00000510766.1, ENST00000689301.1

Conserved Domains (5) summary

cd05093
Location:376 → 663

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

cd00096
Location:49 → 53

Ig; Ig strand A' [structural motif]

cd05855
Location:130 → 223

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:49 → 127

Ig; Immunoglobulin domain

cl15307
Location:1 → 39

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001369536.1 → NP_001356465.1 BDNF/NT-3 growth factors receptor isoform h

Status: REVIEWED

Source sequence(s)

AL390777, AL445532, AL596132

Consensus CDS

CCDS94430.1

UniProtKB/TrEMBL

A0A8I5KUZ1

Related

ENSP00000509020.1, ENST00000692473.1

Conserved Domains (5) summary

cd05093
Location:392 → 679

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

cd00096
Location:49 → 53

Ig; Ig strand A' [structural motif]

cd05855
Location:130 → 223

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:49 → 127

Ig; Immunoglobulin domain

cl15307
Location:1 → 39

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001369537.1 → NP_001356466.1 BDNF/NT-3 growth factors receptor isoform d precursor

Status: REVIEWED

Description

Transcript Variant: This variant (m), as well as variant d, encodes isoform d.

Source sequence(s)

AL390777, AL596132

Consensus CDS

CCDS35051.1

UniProtKB/TrEMBL

A0A8I5KUV8

Related

ENSP00000508829.1, ENST00000687636.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369538.1 → NP_001356467.1 BDNF/NT-3 growth factors receptor isoform e precursor

Status: REVIEWED

Description

Transcript Variant: This variant (n), as well as variant e, encodes isoform e.

Source sequence(s)

AL390777, AL596132

Consensus CDS

CCDS35052.1

UniProtKB/TrEMBL

A0A8I5KUV8

Related

ENSP00000306167.7, ENST00000304053.11

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369539.1 → NP_001356468.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (o), as well as variants b and p-w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000509058.1, ENST00000691415.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369540.1 → NP_001356469.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (p), as well as variants b, o, and q-w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000508443.1, ENST00000688013.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369541.1 → NP_001356470.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (q), as well as variants b, o, p, and r-w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000510451.1, ENST00000689815.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369542.1 → NP_001356471.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (r), as well as variants b, o-q, and s-w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000352906.3, ENST00000359847.4

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369543.1 → NP_001356472.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (s), as well as variants b, o-r, and t-w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000510071.1, ENST00000692762.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369544.1 → NP_001356473.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (t), as well as variants b, o-s, and u-w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000379221.1, ENST00000395882.6

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369545.1 → NP_001356474.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (u), as well as variants b, o-t, v, and w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000509169.1, ENST00000689685.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369546.1 → NP_001356475.1 BDNF/NT-3 growth factors receptor isoform f precursor

Status: REVIEWED

Description

Transcript Variant: This variant (x), as well as variant f, encodes isoform f.

Source sequence(s)

AL390777

Consensus CDS

CCDS94428.1

UniProtKB/TrEMBL

A0A8I5KR47, A0A8I5QKP8

Related

ENSP00000509145.1, ENST00000693127.1

Conserved Domains (6) summary

cd05855
Location:288 → 366

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

cl15307
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

pfam07679
Location:205 → 283

I-set; Immunoglobulin I-set domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat
NM_001369547.1 → NP_001356476.1 BDNF/NT-3 growth factors receptor isoform j precursor

Status: REVIEWED

Source sequence(s)

AL390777

UniProtKB/TrEMBL

A0A8I5KUV8

Related

ENSP00000508947.1, ENST00000690163.1

Conserved Domains (6) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

cl15307
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

pfam07679
Location:205 → 283

I-set; Immunoglobulin I-set domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat
NM_001369548.1 → NP_001356477.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (v), as well as variants b, o-u, and w, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369549.1 → NP_001356478.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (w), as well as variants b and o-v, encodes isoform b.

Source sequence(s)

AL390777

Consensus CDS

CCDS35053.1

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000510717.1, ENST00000687148.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001369550.1 → NP_001356479.1 BDNF/NT-3 growth factors receptor isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (y), as well as variants z and aa, encodes isoform k.

Source sequence(s)

AL390777

Consensus CDS

CCDS94429.1

Related

ENSP00000510032.1, ENST00000686322.1

Conserved Domains (4) summary

cd00096
Location:49 → 53

Ig; Ig strand A' [structural motif]

cd05855
Location:130 → 223

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:49 → 127

Ig; Immunoglobulin domain

cl15307
Location:1 → 39

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001369551.1 → NP_001356480.1 BDNF/NT-3 growth factors receptor isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (z), as well as variants y and aa, encodes isoform k.

Source sequence(s)

AL390777

Consensus CDS

CCDS94429.1

Conserved Domains (4) summary

cd00096
Location:49 → 53

Ig; Ig strand A' [structural motif]

cd05855
Location:130 → 223

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:49 → 127

Ig; Immunoglobulin domain

cl15307
Location:1 → 39

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001369552.1 → NP_001356481.1 BDNF/NT-3 growth factors receptor isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (aa), as well as variants y and z, encodes isoform k.

Source sequence(s)

AL390777

Consensus CDS

CCDS94429.1

Related

ENST00000691567.1

Conserved Domains (4) summary

cd00096
Location:49 → 53

Ig; Ig strand A' [structural motif]

cd05855
Location:130 → 223

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:49 → 127

Ig; Immunoglobulin domain

cl15307
Location:1 → 39

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_006180.6 → NP_006171.2 BDNF/NT-3 growth factors receptor isoform a precursor

See identical proteins and their annotated locations for NP_006171.2

Status: REVIEWED

Source sequence(s)

AL390777, AL445532, AL596132

Consensus CDS

CCDS6671.1

UniProtKB/TrEMBL

A0A8I5KVH8

Related

ENSP00000277120.3, ENST00000277120.8

Conserved Domains (6) summary

cd05093
Location:548 → 835

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

84668522..85027054

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017014751.3 → XP_016870240.1 BDNF/NT-3 growth factors receptor isoform X1

UniProtKB/TrEMBL

A0A8I5KVH8

Conserved Domains (6) summary

cd05093
Location:548 → 835

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_017014753.3 → XP_016870242.1 BDNF/NT-3 growth factors receptor isoform X2

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

A0A8I5KVH8, Q548C2

Related

ENSP00000510060.1, ENST00000686496.1

Conserved Domains (6) summary

cd05093
Location:532 → 819

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_047423432.1 → XP_047279388.1 BDNF/NT-3 growth factors receptor isoform X1
XM_017014752.2 → XP_016870241.1 BDNF/NT-3 growth factors receptor isoform X2

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

A0A8I5KVH8, Q548C2

Related

ENSP00000510619.1, ENST00000692181.1

Conserved Domains (6) summary

cd05093
Location:532 → 819

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_005252001.4 → XP_005252058.1 BDNF/NT-3 growth factors receptor isoform X1

See identical proteins and their annotated locations for XP_005252058.1

UniProtKB/TrEMBL

A0A8I5KVH8

Related

ENSP00000510134.1, ENST00000686324.1

Conserved Domains (6) summary

cd05093
Location:548 → 835

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_011518718.4 → XP_011517020.1 BDNF/NT-3 growth factors receptor isoform X2

See identical proteins and their annotated locations for XP_011517020.1

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

A0A8I5KVH8, Q548C2

Related

ENSP00000509401.1, ENST00000691788.1

Conserved Domains (6) summary

cd05093
Location:532 → 819

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_005252003.4 → XP_005252060.1 BDNF/NT-3 growth factors receptor isoform X1

See identical proteins and their annotated locations for XP_005252060.1

UniProtKB/TrEMBL

A0A8I5KVH8

Conserved Domains (6) summary

cd05093
Location:548 → 835

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_047423433.1 → XP_047279389.1 BDNF/NT-3 growth factors receptor isoform X1
XM_005252004.3 → XP_005252061.1 BDNF/NT-3 growth factors receptor isoform X1

See identical proteins and their annotated locations for XP_005252061.1

UniProtKB/TrEMBL

A0A8I5KVH8

Conserved Domains (6) summary

cd05093
Location:548 → 835

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_017014755.1 → XP_016870244.1 BDNF/NT-3 growth factors receptor isoform X3

UniProtKB/TrEMBL

A0A8I5KUV8

Related

ENSP00000510640.1, ENST00000693539.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_017014760.3 → XP_016870249.1 BDNF/NT-3 growth factors receptor isoform X4

UniProtKB/TrEMBL

A0A8I5QKP8, Q5VWE5

Related

ENSP00000508497.1, ENST00000692389.1

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

96818888..97177857

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054363020.1 → XP_054218995.1 BDNF/NT-3 growth factors receptor isoform X1
XM_054363024.1 → XP_054218999.1 BDNF/NT-3 growth factors receptor isoform X2

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

Q548C2
XM_054363018.1 → XP_054218993.1 BDNF/NT-3 growth factors receptor isoform X1
XM_054363026.1 → XP_054219001.1 BDNF/NT-3 growth factors receptor isoform X2

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

Q548C2
XM_054363019.1 → XP_054218994.1 BDNF/NT-3 growth factors receptor isoform X1
XM_054363025.1 → XP_054219000.1 BDNF/NT-3 growth factors receptor isoform X2

UniProtKB/Swiss-Prot

B1ANZ4, B4DFV9, Q16620, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7

UniProtKB/TrEMBL

Q548C2
XM_054363021.1 → XP_054218996.1 BDNF/NT-3 growth factors receptor isoform X1
XM_054363022.1 → XP_054218997.1 BDNF/NT-3 growth factors receptor isoform X1
XM_054363023.1 → XP_054218998.1 BDNF/NT-3 growth factors receptor isoform X1
XM_054363027.1 → XP_054219002.1 BDNF/NT-3 growth factors receptor isoform X3
XM_054363028.1 → XP_054219003.1 BDNF/NT-3 growth factors receptor isoform X4

UniProtKB/TrEMBL

Q5VWE5