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    SIK3 SIK family kinase 3 [ Homo sapiens (human) ]

    Gene ID: 23387, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SIK3provided by HGNC
    Official Full Name
    SIK family kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:29165
    See related
    Ensembl:ENSG00000160584 MIM:614776; AllianceGenome:HGNC:29165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L19; QSK; SEMDK; SIK-3
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 19.2), brain (RPKM 13.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SIK3 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (116843402..117098428, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (116858511..117113691, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (116714118..116969144, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116700143-116701075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3925 Neighboring gene APOA1 antisense RNA Neighboring gene apolipoprotein C3 Neighboring gene apolipoprotein A1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5558 Neighboring gene OCT4 hESC enhancer GRCh37_chr11:116766707-116767208 Neighboring gene MPRA-validated peak1483 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3927 Neighboring gene MPRA-validated peak1484 silencer Neighboring gene MPRA-validated peak1485 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:116881555-116882207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5561 Neighboring gene RNY4 pseudogene 6 Neighboring gene ribosomal protein S27 pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5563 Neighboring gene MPRA-validated peak1487 silencer Neighboring gene uncharacterized LOC124902763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3930 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:116979894-116980128 Neighboring gene cleavage and polyadenylation specificity factor subunit 5-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117008445-117009330 Neighboring gene proprotein convertase subtilisin/kexin type 7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. Charoenfuprasert S, et al. Oncogene, 2011 Aug 18. PMID 21399663
    2. Salt-Inducible Kinase 3 Haplotypes Associated with Noise-Induced Hearing Loss in Chinese Workers. Yin H, et al. Audiol Neurootol, 2020. PMID 32126566
    3. Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer. Huang CJ, et al. J Cell Mol Med, 2008 Oct. PMID 18266979, Free PMC Article
    4. [Analysis of SIK3 gene variation in a boy with autism spectrum disorder complicated with epilepsy]. Jia X, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2021 Dec 10. PMID 34839513
    5. Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation. Amara S, et al. PLoS One, 2017. PMID 28658303, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.
      Title: Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.
    2. [Analysis of SIK3 gene variation in a boy with autism spectrum disorder complicated with epilepsy].
      Title: [Analysis of SIK3 gene variation in a boy with autism spectrum disorder complicated with epilepsy].
    3. High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms.
      Title: High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms.
    4. Salt-Inducible Kinase 3 Haplotypes Associated with Noise-Induced Hearing Loss in Chinese Workers.
      Title: Salt-Inducible Kinase 3 Haplotypes Associated with Noise-Induced Hearing Loss in Chinese Workers.
    5. Salt-inducible Kinases Are Critical Determinants of Female Fertility.
      Title: Salt-inducible Kinases Are Critical Determinants of Female Fertility.
    6. Salt-inducible kinases (SIKs) regulate TGFbeta-mediated transcriptional and apoptotic responses.
      Title: Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.
    7. An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.
      Title: An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.
    8. Targeting of LKB1 or SIK3 diminishes histone acetylation at MEF2C-bound enhancers and deprives leukemia cells of the output of this essential TF.
      Title: LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.
    9. Data suggest that cAMP/protein kinase A-dependent phosphorylation of SIK1, SIK2, and SIK3 inhibits their catalytic activity by inducing 14-3-3 protein binding.
      Title: 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
    10. role in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation
      Title: Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Spondyloepimetaphyseal dysplasia, Krakow type
    MedGen: C4748455 OMIM: 618162 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
    EBI GWAS Catalog
    Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
    EBI GWAS Catalog
    Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
    EBI GWAS Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog
    Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.
    EBI GWAS Catalog
    Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12240, KIAA0999

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SIK3
    Names
    salt-inducible kinase 3
    serine/threonine-protein kinase QSK
    NP_001268677.1
    NP_001268678.1
    NP_001353615.1
    NP_001353616.1
    NP_079440.3
    XP_005271539.2
    XP_005271541.2
    XP_005271542.1
    XP_011541024.1
    XP_011541025.1
    XP_011541026.1
    XP_011541027.1
    XP_011541028.1
    XP_016872913.1
    XP_016872914.1
    XP_016872915.1
    XP_047282627.1
    XP_047282628.1
    XP_047282629.1
    XP_047282630.1
    XP_047282631.1
    XP_047282632.1
    XP_054224194.1
    XP_054224195.1
    XP_054224196.1
    XP_054224197.1
    XP_054224198.1
    XP_054224199.1
    XP_054224200.1
    XP_054224201.1
    XP_054224202.1
    XP_054224203.1
    XP_054224204.1
    XP_054224205.1
    XP_054224206.1
    XP_054224207.1
    XP_054224208.1
    XP_054224209.1
    XP_054224210.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281748.3 → NP_001268677.1  serine/threonine-protein kinase SIK3 isoform 2

      See identical proteins and their annotated locations for NP_001268677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI369377, AP000936, AP006216, BC128511
      UniProtKB/TrEMBL
      A1A5A9, M5FMX3
      Conserved Domains (3) summary
      smart00220
      Location:1 → 158
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14410
      Location:187 → 231
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cl21453
      Location:1 → 158
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001281749.3 → NP_001268678.1  serine/threonine-protein kinase SIK3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This results in a shorter isoform (3) compared to isoform 1.
      Source sequence(s)
      AI369377, AP000936, AP006216, BC128510
      Consensus CDS
      CCDS60974.1
      UniProtKB/TrEMBL
      M5FMX3
      Related
      ENSP00000390442.2, ENST00000446921.6
      Conserved Domains (1) summary
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    3. NM_001366686.3 → NP_001353615.1  serine/threonine-protein kinase SIK3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AP000936, AP003070, AP006216
      Consensus CDS
      CCDS91600.1
      UniProtKB/TrEMBL
      H0Y4E8, M5FMX3
      Related
      ENSP00000391295.2, ENST00000445177.6
      Conserved Domains (2) summary
      cd14410
      Location:346 → 390
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    4. NM_001366687.1 → NP_001353616.1  serine/threonine-protein kinase SIK3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AP000936, AP003070, BC121188
      UniProtKB/TrEMBL
      Q0IJ40
      Conserved Domains (1) summary
      cl21453
      Location:65 → 205
      PKc_like; Protein Kinases, catalytic domain

    5. NM_025164.6 → NP_079440.3  serine/threonine-protein kinase SIK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AB023216, AI369377, AP000936, AP006216
      Consensus CDS
      CCDS8379.2
      UniProtKB/Swiss-Prot
      A1A5A8, H0Y494, J3KPC8, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50, Q9Y2K2
      UniProtKB/TrEMBL
      M5FMX3
      Related
      ENSP00000364449.1, ENST00000375300.6
      Conserved Domains (2) summary
      cd14410
      Location:346 → 390
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      116843402..117098428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017424.2 → XP_016872913.1  serine/threonine-protein kinase SIK3 isoform X6

      UniProtKB/TrEMBL
      M5FMX3

    2. XM_047426672.1 → XP_047282628.1  serine/threonine-protein kinase SIK3 isoform X4

      UniProtKB/TrEMBL
      M5FMX3

    3. XM_005271482.5 → XP_005271539.2  serine/threonine-protein kinase SIK3 isoform X2

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (2) summary
      smart00220
      Location:66 → 317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    4. XM_005271484.4 → XP_005271541.2  serine/threonine-protein kinase SIK3 isoform X5

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (2) summary
      cd14410
      Location:346 → 390
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    5. XM_011542722.2 → XP_011541024.1  serine/threonine-protein kinase SIK3 isoform X3

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (2) summary
      cd14410
      Location:346 → 390
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    6. XM_011542725.3 → XP_011541027.1  serine/threonine-protein kinase SIK3 isoform X7

      See identical proteins and their annotated locations for XP_011541027.1

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (3) summary
      smart00220
      Location:1 → 158
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14410
      Location:187 → 231
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cl21453
      Location:1 → 158
      PKc_like; Protein Kinases, catalytic domain

    7. XM_011542724.3 → XP_011541026.1  serine/threonine-protein kinase SIK3 isoform X7

      See identical proteins and their annotated locations for XP_011541026.1

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (3) summary
      smart00220
      Location:1 → 158
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14410
      Location:187 → 231
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cl21453
      Location:1 → 158
      PKc_like; Protein Kinases, catalytic domain

    8. XM_011542723.3 → XP_011541025.1  serine/threonine-protein kinase SIK3 isoform X7

      See identical proteins and their annotated locations for XP_011541025.1

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (3) summary
      smart00220
      Location:1 → 158
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14410
      Location:187 → 231
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cl21453
      Location:1 → 158
      PKc_like; Protein Kinases, catalytic domain

    9. XM_017017425.2 → XP_016872914.1  serine/threonine-protein kinase SIK3 isoform X7

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (3) summary
      smart00220
      Location:1 → 158
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14410
      Location:187 → 231
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cl21453
      Location:1 → 158
      PKc_like; Protein Kinases, catalytic domain

    10. XM_017017426.2 → XP_016872915.1  serine/threonine-protein kinase SIK3 isoform X7

      UniProtKB/TrEMBL
      M5FMX3
      Conserved Domains (3) summary
      smart00220
      Location:1 → 158
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14410
      Location:187 → 231
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cl21453
      Location:1 → 158
      PKc_like; Protein Kinases, catalytic domain

    11. XM_047426673.1 → XP_047282629.1  serine/threonine-protein kinase SIK3 isoform X9

      UniProtKB/TrEMBL
      B3KVE2
      Related
      ENST00000488337.5

    12. XM_005271485.4 → XP_005271542.1  serine/threonine-protein kinase SIK3 isoform X8

      UniProtKB/TrEMBL
      B3KVE2

    13. XM_047426671.1 → XP_047282627.1  serine/threonine-protein kinase SIK3 isoform X1

      UniProtKB/TrEMBL
      H0Y4E8, M5FMX3

    14. XM_011542726.2 → XP_011541028.1  serine/threonine-protein kinase SIK3 isoform X10

      Conserved Domains (2) summary
      cd14410
      Location:346 → 390
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    15. XM_047426674.1 → XP_047282630.1  serine/threonine-protein kinase SIK3 isoform X11

    16. XM_047426676.1 → XP_047282632.1  serine/threonine-protein kinase SIK3 isoform X13

    17. XM_047426675.1 → XP_047282631.1  serine/threonine-protein kinase SIK3 isoform X12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      116858511..117113691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368224.1 → XP_054224199.1  serine/threonine-protein kinase SIK3 isoform X6

      UniProtKB/TrEMBL
      M5FMX3

    2. XM_054368222.1 → XP_054224197.1  serine/threonine-protein kinase SIK3 isoform X4

      UniProtKB/TrEMBL
      M5FMX3

    3. XM_054368220.1 → XP_054224195.1  serine/threonine-protein kinase SIK3 isoform X2

      UniProtKB/TrEMBL
      M5FMX3

    4. XM_054368223.1 → XP_054224198.1  serine/threonine-protein kinase SIK3 isoform X5

      UniProtKB/TrEMBL
      M5FMX3

    5. XM_054368221.1 → XP_054224196.1  serine/threonine-protein kinase SIK3 isoform X3

      UniProtKB/TrEMBL
      M5FMX3

    6. XM_054368229.1 → XP_054224204.1  serine/threonine-protein kinase SIK3 isoform X7

      UniProtKB/TrEMBL
      M5FMX3

    7. XM_054368227.1 → XP_054224202.1  serine/threonine-protein kinase SIK3 isoform X7

      UniProtKB/TrEMBL
      M5FMX3

    8. XM_054368225.1 → XP_054224200.1  serine/threonine-protein kinase SIK3 isoform X7

      UniProtKB/TrEMBL
      M5FMX3

    9. XM_054368226.1 → XP_054224201.1  serine/threonine-protein kinase SIK3 isoform X7

      UniProtKB/TrEMBL
      M5FMX3

    10. XM_054368228.1 → XP_054224203.1  serine/threonine-protein kinase SIK3 isoform X7

      UniProtKB/TrEMBL
      M5FMX3

    11. XM_054368231.1 → XP_054224206.1  serine/threonine-protein kinase SIK3 isoform X9

      UniProtKB/TrEMBL
      B3KVE2

    12. XM_054368230.1 → XP_054224205.1  serine/threonine-protein kinase SIK3 isoform X8

      UniProtKB/TrEMBL
      B3KVE2

    13. XM_054368219.1 → XP_054224194.1  serine/threonine-protein kinase SIK3 isoform X1

      UniProtKB/TrEMBL
      H0Y4E8, M5FMX3

    14. XM_054368232.1 → XP_054224207.1  serine/threonine-protein kinase SIK3 isoform X10

    15. XM_054368233.1 → XP_054224208.1  serine/threonine-protein kinase SIK3 isoform X11

    16. XM_054368235.1 → XP_054224210.1  serine/threonine-protein kinase SIK3 isoform X13

    17. XM_054368234.1 → XP_054224209.1  serine/threonine-protein kinase SIK3 isoform X12

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2K2.4 GenPept UniProtKB/Swiss-Prot:Q9Y2K2

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