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    Ddx18 DEAD-box helicase 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308490, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ddx18provided by RGD
    Official Full Name
    DEAD-box helicase 18provided by RGD
    Primary source
    RGD:1549712
    See related
    EnsemblRapid:ENSRNOG00000025430 AllianceGenome:RGD:1549712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MrDb
    Summary
    Involved in cellular response to estradiol stimulus. Predicted to be located in chromosome and nucleolus. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 162.4), Spleen (RPKM 130.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddx18 in Genome Data Viewer
    Location:
    13q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (35282391..35296038, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (32729697..32743161, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (37522558..37536066, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 5B Neighboring gene uncharacterized LOC134481622 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 50 Neighboring gene uncharacterized LOC120096234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. Grandori C, et al. EMBO J, 1996 Aug 15. PMID 8861962, Free PMC Article
    2. DExD/H-box RNA helicases in ribosome biogenesis. Martin R, et al. RNA Biol, 2013 Jan. PMID 22922795, Free PMC Article
    3. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Sekiguchi T, et al. Nucleic Acids Res, 2006. PMID 16963496, Free PMC Article
    4. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC95311

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX18
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
    Myc-regulated DEAD box protein
    NP_001006997.1
    XP_063128478.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006996.1 → NP_001006997.1  ATP-dependent RNA helicase DDX18

      See identical proteins and their annotated locations for NP_001006997.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083919
      UniProtKB/TrEMBL
      A6K809, Q5XHY0
      Related
      ENSRNOP00000102608.1, ENSRNOT00000037203.5
      Conserved Domains (4) summary
      smart00487
      Location:198 → 386
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:404 → 533
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:183 → 390
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam13959
      Location:565 → 623
      DUF4217; Domain of unknown function (DUF4217)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      35282391..35296038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272408.1 → XP_063128478.1  ATP-dependent RNA helicase DDX18 isoform X1

      UniProtKB/TrEMBL
      A6K809
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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