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    Rasal3 RAS protein activator like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasal3provided by RGD
    Official Full Name
    RAS protein activator like 3provided by RGD
    Primary source
    RGD:1309019
    See related
    EnsemblRapid:ENSRNOG00000006167 AllianceGenome:RGD:1309019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309019
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and positive regulation of NK T cell proliferation. Predicted to be located in cytoplasm and cytoplasmic side of membrane. Orthologous to human RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 200.6), Spleen (RPKM 109.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rasal3 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12047090..12061883, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11396554..11411347, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14403592..14419570, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479821 Neighboring gene WIZ zinc finger Neighboring gene uncharacterized LOC134479820 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene uncharacterized LOC134479822 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. Saito S, et al. Eur J Immunol, 2015 May. PMID 25652366
    2. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAS protein activator like-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134562.3 → NP_001128034.1  RAS protein activator like-3 isoform 2

      See identical proteins and their annotated locations for NP_001128034.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZJL7, A6K948, D3ZWW3
      Related
      ENSRNOP00000059964.1, ENSRNOT00000066722.3
      Conserved Domains (5) summary
      cd05136
      Location:420 → 743
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12329
      Location:890 → 950
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      cl14603
      Location:296 → 428
      C2; C2 domain
      cl17171
      Location:177 → 323
      PH-like; Pleckstrin homology-like domain
      cl19398
      Location:752 → 859
      Rep_3; Initiator Replication protein

    2. NM_001414936.1 → NP_001401865.1  RAS protein activator like-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZJL7, A0A8I6GE24
      Related
      ENSRNOP00000086442.1, ENSRNOT00000104813.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      12047090..12061883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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